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右美托咪定对肺癌手术患者免疫功能和微循环的影响
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| 篇名： | 右美托咪定对肺癌手术患者免疫功能和微循环的影响 |
| TITLE： | |
| 摘要： | 目的：探讨右美托咪定对肺癌手术患者免疫功能和微循环的影响。方法：选择择期行肺癌手术患者88例，按随机数字表法分为观察组和对照组，各44例。观察组患者麻醉诱导前10 min静脉注射右美托咪定负荷剂量1 μg/kg，并以0.6 μg/（kg·h）静脉滴注至关胸；对照组患者静脉注射等量0.9％氯化钠注射液。观察两组患者麻醉诱导开始时（T0）、手术结束即刻（T1）、术后12 h （T2）时的CD3+、CD4+、CD8+水平及CD4+/CD8+、末梢灌注指数（TPI）、低频功率（LF）/高频功率（HF）值，并比较两组患者不良反应发生情况。结果：T0时，两组患者CD3+、CD4+、CD8+、CD4+/CD8+、TPI、LF/HF比较，差异均无统计学意义（P＞0.05）。T1、T2时，对照组患者CD3+、CD4+、CD4+/CD8+ 、TPI显著降低，且显著低于观察组；CD8+显著升高，且显著高于观察组；两组患者LF/HF均显著降低，且观察组显著低于对照组，差异均有统计学意义（P＜0.05）。观察组患者的CD3+、CD4+、CD8+、CD4+/CD8+、TPI治疗前后比较，差异均无统计学意义（P＞0.05）。两组患者不良反应发生率比较，差异无统计学意义（P＞0.05）。结论：右美托咪定可有效稳定肺癌手术患者术中的免疫功能和微循环，且不增加不良反应。 |
| ABSTRACT： | OBJECTIVE： To explore the influence of dextral metoprolol on immunologic function and nicrocirculation of patients undergoing lung cancer surgery. METHODS： 88 patients undergoing selective lung cancer surgery were selected and divided into observation group and control group according to random number method， with 44 cases in each group. Observation group was given intravenous infusion of dextral metoprolol with loading dose of 1 μg/kg 10 min before anesthesia induction， then at 0.6 μg/（kg·h） until closing the chest； control group was given constant volume of 0.9％ Sodium chloride injection with intravenous infusion. The levels of CD3+， CD4+， CD8+ and CD4+/CD8+， as well as the TPI， LF/HF ratio were observed in 2 groups at the beginning of anesthesia induction （T0）， immediately after the end of surgery （T1）， 12 h after surgery （T2）； the occurrence of ADR were compared between 2 groups. RESULTS： There was no statistical significance in the levels of CD3+， CD4+， CD8+， CD4+/CD8+， TPI and LF/HF between 2 groups at T0 （P＞0.05）. At T1 and T2， CD3+， CD4+， CD4+/CD8+ and TPI of control group were decreased significantly and lower than those of observation group； CD8+ in control group were increased significantly and higher than observation group； LF/HF of both groups were deereased significantly， and the observation group was significantly lower than the control group， with statistical significance （P＜0.05）. There was no statistical significance in CD3+、CD4+、CD8+、CD4+/CD8+ and TPI of observation group before and after treatment （P＞0.05）. There was no statistical significance in the incidence of ADR between 2 groups （P＞0.05）. CONCLUSIONS： Dextral metoprolol can effectively improve the immunologic function and microcirculation of patients during lung cancer surgery with good safety. |
| 期刊： | 2017年第28卷第2期 |
| 作者： | 陈英，洪道先，宋直雷，何东海 |
| AUTHORS： | CHEN Ying，HONG Daoxian，SONG Zhilei，HE Donghai |
| 关键字： | 右美托咪定；肺癌手术；免疫功能；微循环 |
| KEYWORDS： | Dextral metoprolol； Lung cancer surgery； Immunologic function； Microcirculation |
| 阅读数： | 308 次 |
| 本月下载数： | 2 次 |
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