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益气化瘀颗粒对小鼠胃肠动力和大鼠血液流变学的影响
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| 篇名： | 益气化瘀颗粒对小鼠胃肠动力和大鼠血液流变学的影响 |
| TITLE： | |
| 摘要： | 目的：考察益气化瘀颗粒对胃肠动力障碍模型小鼠胃肠动力及急性血瘀模型大鼠血液流变学的影响，为其临床使用提供实验依据。方法：将50只ICR小鼠随机分为正常组、模型组、莫沙必利组（阳性对照化学药，0.003 g/kg）、木香顺气丸组（阳性对照中药，0.36 g/kg）和益气化瘀颗粒组（2.4 g/kg），每组10只。各给药组小鼠ig相应药物溶液，每天1次，连续1周；正常组和模型组小鼠ig生理盐水。末次给药后禁食24 h，再按上述剂量ig给药1 h后，除正常组外其余各组小鼠均ig硫酸阿托品溶液复制胃肠动力障碍模型，测定小鼠胃内残留率和小肠推进率。将60只SD大鼠随机分为正常组、模型组、复方丹参片组（阳性对照，1.0 g/kg）和益气化瘀颗粒高、中、低剂量组（2.4、1.2、0.6 g/kg），每组10只。正常组和模型组大鼠ig生理盐水，各给药组大鼠ig相应药物溶液，每天1次，连续1周。末次给药1 h后，除正常组外，其余各组大鼠均通过ip肾上腺素+冰水处理复制急性血瘀模型。测定大鼠全血黏度（高、中、低切），血浆黏度，血细胞比容，1、3、5 min内的血小板聚集率和最大血小板聚集率。结果：与正常组比较，模型组小鼠胃内残留率显著升高（P＜0.01），小肠推进率显著降低（P＜0.01）；模型组大鼠全血黏度（高、中、低切）、血浆黏度、血细胞比容和1、3、5 min内的血小板聚集率以及最大血小板聚集率均显著升高（P＜0.01）。与模型组比较，各给药组小鼠/大鼠上述指标均显著改善（P＜0.05或P＜0.01）。结论：益气化瘀颗粒具有明显的促进胃肠蠕动和抗凝作用。 |
| ABSTRACT： | OBJECTIVE： To investigate the effects of Yiqi huayu granules on gastrointestinal motility of gastrointestinal motility disorder model mice and blood rheology of acute blood stasis model rats， and to provide experimental evidence for clinical use of it. METHODS： 50 ICR mice were randomly divided into normal group， model group， mosapride group （positive control chemical drug， 0.003 g/kg）， Muxiang shunqi pills group （positive control TCM， 0.36 g/kg） and Yiqi huayu granules group （2.4 g/kg）， with 10 mice in each group. Treatment groups were given relevant medicine solution intragastrically， once a day， for a week； normal group and model group were given normal saline intragastrically. Those groups fasted for 24 h after last medication， and then were given above medicine intragastrically； 1 h later， they were given atropine sulfate intragastrically to induce gastrointestinal motility disorder model except for normal control group. The stomach residue rate and intestinal propulsive rate of mice were measured. 60 SD rats were randomly divided into normal group， model group， Compound danshen tablet group （positive control， 1.0 g/kg） and Yiqi huayu granules high-dose， medium-dose and low-dose groups （2.4， 1.2， 0.6 g/kg）， with 10 rats in each group. Normal group and model group were given normal saline intragastrically， and treatment groups were given relevant medicine， once a day， for a week. 1 h after last medication， those groups were given adrenaline intraperitoneally+aqua astricta. to induce acute blood stasis model except for normal group. The whole blood viscosity （high-shearing， middle-shearing，low-shearing）， plasma viscosity， 1， 3， 5 min platelet aggregation rate ， hematocrit and maximal platelet aggregation rate were all detected in rats. RESULTS： Compared with normal group， stomach residue rate of mice in model group was increased significantly （P＜0.01）， while intestinal propulsive rate was decreased significantly （P＜0.01）. The whole blood viscosity （high-shearing， middle-shearing，low-shearing）， plasma viscosity， hematocrit， 1， 3， 5 min platelet aggregation rate and maximal platelet aggregation rate of rats were all increased significantly in model group （P＜0.01）. Compared with model group， above indexes of mice/rats were all improved significantly in treatment groups （P＜0.05 or P＜0.01）. CONCLUSIONS： Yiqi huayu granules can significantly promote the function of gastrointestinal peristalsis and anticoagulation. |
| 期刊： | 2017年第28卷第4期 |
| 作者： | 李世东，吴文波，尹慧荣，刘兴，王亚靖 |
| AUTHORS： | LI Shidong，WU Wenbo，YIN Huirong，LIU Xing，WANG Yajing |
| 关键字： | 益气化瘀颗粒；胃肠动力；血液流变学；血小板聚集率；大鼠；小鼠 |
| KEYWORDS： | Yiqi huayu granules； Gastrointestinal motility； Blood rheology； Platelet aggregation rate； Rat； Mice |
| 阅读数： | 317 次 |
| 本月下载数： | 7 次 |
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