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氯诺昔康治疗膝骨性关节炎的临床观察
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| 篇名： | 氯诺昔康治疗膝骨性关节炎的临床观察 |
| TITLE： | |
| 摘要： | 目的：考察氯诺昔康对膝骨性关节炎患者的疗效及疼痛程度的作用。方法：选择我院2014年1月－2016年1月膝骨性关节炎患者120例，按治疗方案的不同分为对照组和观察组，各60例。对照组患者给予布洛芬缓释胶囊0.3 g，bid，进行常规治疗；观察组患者在对照组基础上给予氯诺昔康8 mg，bid。两组患者均治疗4周。比较两组患者治疗前后视觉模拟（VAS）评分、临床疗效及不良反应发生情况。结果：治疗前两组患者VAS评分比较，差异无统计学意义（P＞0.05）；治疗后，两组患者VAS评分显著降低，且观察组显著低于对照组，差异有统计学意义（P＜0.05）。观察组患者临床有效率为95.0％，显著高于对照组的75.0％，差异有统计学意义（P＜0.05）。观察组患者不良反应发生率为3.33％，显著低于对照组的11.67％，差异有统计学意义（P＜0.05）。结论：氯诺昔康治疗膝骨性关节炎疗效显著，能明显减轻患者疼痛程度，且安全性较好。 |
| ABSTRACT： | OBJECTIVE： To investigate the therapeutic efficacy of celecoxib in the treatment of knee osteoarthritis and its effects on patin degree. METHODS： One hundred and twenty cases of knee osteoarthritis were selected from our hospital during Jan. 2014 to Jan. 2016， and then divided into control group and observation group according to therapy plan， with 60 cases in each group. Control group was given Ibuprofen sustained-release capsule 0.3 g， bid； observation group was additionally given lornoxicam 8 mg， bid， on the basis of control group. Both groups were treated for 4 weeks. VAS score was compared between 2 groups before and after treatment， and clinical efficacy and the occurrence of ADR were observed in 2 groups. RESULTS： There was no statistical significance in VAS score between 2 groups before treatment （P＞0.05）. After treatment， VAS score of 2 groups were decreased significantly， and the observation group was significantly lower than the control group， with statistical significance （P＜0.05）. Clinical response rate of observation group was 95.0％， which was significantly higher than 75.0％ of control group， with statistical significance （P＜0.05）. The incidence of ADR was 3.33％ in observation group， which was significantly lower than 11.67％ of control group， with statistical significance （P＜0.05）. CONCLUSIONS： Lornoxicam is effective for knee osteoarthritis and can significantly improve pain with good safety. |
| 期刊： | 2017年第28卷第5期 |
| 作者： | 宋晓飞，张长成 |
| AUTHORS： | SONG Xiaofei，ZHANG Changcheng |
| 关键字： | 氯诺昔康；膝骨性关节炎；功能恢复；疗效 |
| KEYWORDS： | Lornoxicam； Knee osteoarthritis； Functional recovery； Therapeutic efficacy |
| 阅读数： | 442 次 |
| 本月下载数： | 3 次 |
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