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藏药复方多血康胶囊对脂多糖诱导急性肺损伤小鼠的保护作用
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| 篇名： | 藏药复方多血康胶囊对脂多糖诱导急性肺损伤小鼠的保护作用 |
| TITLE： | |
| 摘要： | 目的：考察藏药复方多血康胶囊对脂多糖诱导急性肺损伤小鼠的保护作用。方法：将60只KM小鼠随机分为空白组、模型组、地塞米松组（阳性对照，1 mg/kg）和复方多血康胶囊高、中、低剂量组（3.6、1.8、0.9 g/kg，以生药计），每组10只。ig给药，空白组和模型组小鼠ig等体积生理盐水，每天1次。连续给药7 d后，除空白组外，其余各组小鼠均ip脂多糖诱导急性肺损伤。造模6 h后，观察小鼠肺组织病理改变，测量肺组织含水量，检测肺组织中超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GSH-Px）、丙二醛（MDA）水平以及血清中白细胞介素6（IL-6）、肿瘤坏死因子α（TNF-α）水平。结果：与空白组比较，模型组小鼠肺组织发生充血水肿、炎症细胞浸润、肺泡间隔及肺泡壁明显增宽等病理变化，肺组织含水量和肺组织中MDA水平以及血清中IL-6、TNF-α水平均显著升高（P＜0.01），肺组织中SOD、GSH-Px水平显著降低（P＜0.05）。与模型组比较，各给药组小鼠肺组织损伤程度均不同程度降低；除复方多血康胶囊低剂量组大鼠肺组织含水量、肺组织中MDA水平以及血清中TNF-α水平变化不明显外，其余各给药组小鼠上述指标均显著改善（P＜0.05或P＜0.01）。结论：藏药复方多血康胶囊可明显减轻小鼠氧化应激和炎症反应，对脂多糖诱导的急性肺损伤小鼠有一定保护作用。 |
| ABSTRACT： | OBJECTIVE： To investigate the protective effect of Tibetan medicine Compound Duoxuekang capsules on the acute lung injury in mice induced by lipopolysaccharide. METHODS： 60 KM mice were randomly divided into blank group， model group， dexamethasone group （positive control， 1 mg/kg） and Compound Duoxuekang high-dose， medium-dose， low-dose groups （3.6， 1.8， 0.9 g/kg， calculated by crude drug），10 in each group. Intragastrically administrated， mice in blank group and model group intragastrically administrated equal volume of normal saline， once a day. After 7 d of administration， except for blank group， mice in other groups intraperitoneally injected lipopolysaccharide to induce acute lung injury. After 6 h modeling， pathological changes in the lung tissue was observed， lung tissue water content was measured， superoxide dismutase （SOD）， glutathione peroxidase （GSH-Px）， malondialdehyde （MDA） levels in lung tissue and IL-6， TNF-α levels in serum were detected. RESULTS： Compared with blank group， mice in model group showed pathological changes in congestion and edema， inflammatory cell infiltration， obvious widened alveolar septum and alveolar wall； water content in lung tissue and IL-6， TNF-α levels in serum were significantly increased （P＜0.01）； SOD， GSH-Px levels in lung tissue were significantly decreased （P＜0.01）. Compared with model group， injury degree of lung tissue reduced to varying degrees in each treatment group， except for the water content， MDA level in lung tissue and TNF-α level in serum in Compound Duoxuekang capsules low-dose group； the above-mentioned indexes in other groups were significantly improved （P＜0.05 or P＜0.01）. CONCLUSIONS： Compound Duoxuekang capsules can obviously reduce mice’s oxidative stress and inflammatory response， and has certain protective effect on acute lung injury in mice. |
| 期刊： | 2017年第28卷第7期 |
| 作者： | 胡晓鑫，罗强，杜蕾蕾，张艺，降拥四郎 |
| AUTHORS： | HU Xiaoxin，LUO Qiang，DU Leilei，ZHANG Yi，JIANGYONG Silang |
| 关键字： | 藏药；复方多血康胶囊；急性肺损伤；炎症；氧化应激；小鼠 |
| KEYWORDS： | Tibetan medicine； Compound Duoxuekang capsules ； Acute lung injury； Inflammation； Oxidative stress； Mice |
| 阅读数： | 310 次 |
| 本月下载数： | 3 次 |
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