我院72例碘比醇注射液致药品不良反应分析
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篇名: 我院72例碘比醇注射液致药品不良反应分析
TITLE:
摘要: 目的:探讨临床应用碘比醇注射液致药品不良反应(ADR)发生的特点及规律,为临床合理用药提供参考。方法:采用回顾性研究方法,收集2015年7月-2016年7月在我院应用碘比醇注射液出现ADR的72例患者的相关信息,按照年龄、性别、原患疾病、ADR累及器官/系统及临床表现、关联性评价及等级、出现时间、转归情况等进行统计分析。结果:72例ADR患者中女性为男性的2倍,年龄集中在50~80岁(80.56%);ADR累及器官/系统以皮肤及其附件所占比例最高(30.57%),其次为全身性反应(22.93%)和循环系统(21.66%);ADR多在用药后20 min内发生(38.89%)。ADR转归方面,痊愈占58.33%,好转占41.67%。结论:碘比醇注射液临床应用过程中,应详细了解患者的病情、病史及各项检查结果,告知患者可能出现的过敏症状,并做好急救准备。
ABSTRACT: OBJECTIVE: To investigate the characteristics and regularity of ADR induced by Iobitridol injection, and to provide reference for clinical drug use. METHODS: In retrospective study, the information of 72 patients suffering from ADR induced by Iobitridol injection were collected from our hospital during Jul. 2015 to Jul. 2016, and then statistical analysis was conducted in respects of age, gender, primary disease, organs/system involved in ADR, clinical manifestations, relationship evaluation and degree, occurrence time, outcomes, etc. RESULTS: Among 72 cases of ADR, the number of female was about twice of that in male. The age mainly distributed in the range of 50 to 80 years old (80.56%). ADR mainly occurred in skin and its appendants (30.57%), followed by systemic reactions (22.93%) and circulatory system (21.66%). ADR occurred within 20 min after medication (38.89%). 58.33% of ADR patients were cured, and 41.67% were recovered. CONCLUSIONS: During the application of Iobitridol injection, a detailed understanding should be obtained about the patient’s condition, medical history and the results of the examinations. Medical staff should inform the patient of the possible allergic symptoms, and do a good emergency preparation.
期刊: 2017年第28卷第8期
作者: 李宁,马满玲
AUTHORS: LI Ning,MA Manling
关键字: 碘比醇注射液;药品不良反应;合理用药
KEYWORDS: Iobitridol injection; Adverse drug reaction; Rational drug use
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