靳三针结合加味乌梅丸治疗围绝经期失眠的临床观察
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篇名: | 靳三针结合加味乌梅丸治疗围绝经期失眠的临床观察 |
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摘要: | 目的:观察靳三针联合加味乌梅丸治疗围绝经期失眠的效果及安全性。方法:选取我院2015年10月-2016年3月就诊的围绝经期失眠患者165例。按照随机数字表法分为A组(n=41)、B组(n=41)、C组(n=41)和D组(n=42)。A组患者给予艾司唑仑片1 mg,qd;B组患者采用靳三针疗法30 min/次,qd;C组患者给予加味乌梅丸1丸,于早晚餐后温服;D组患者采用靳三针结合加味乌梅丸治疗(方法同B、C组)。4组患者均治疗4周。观察4组患者治疗前后的匹茨堡睡眠质量指数量表(PSQI)评分、改良Kupperman评分、生活质量评分,血清雌二醇(E2)、卵泡刺激素(FSH)水平,并记录不良反应发生情况。结果:治疗前,上述评分和指标比较,差异均无统计学意义(P>0.05)。治疗后,4组患者PSQI评分、改良Kupperman评分均较治疗前明显降低,且B、C、D组患者明显低于A组,D组患者明显低于B、C组,差异均有统计学意义(P<0.05);4组患者生活质量评分均较治疗前明显升高,且B、C、D组患者明显高于A组,D组患者明显高于B、C组,差异均有统计学意义(P<0.05);B、C、D组患者的E2水平均较治疗前及A组同期明显升高,FSH水平明显降低,且D组患者改善程度明显优于B、C组,差异均有统计学意义(P<0.05)。A组患者不良反应发生率明显高于B、C、D组,差异有显著统计学意义(P<0.01);但B、C、D组患者不良反应发生率比较,差异无统计学差异(P>0.05)。结论:靳三针结合加味乌梅丸治疗围绝经期失眠患者效果较好,且安全性高。 |
ABSTRACT: | OBJECTIVE: To observe the effectiveness and safety of Jin’s three-needle combined with Jiawei wumei pill in the treatment of menopausal insomnia. METHODS: One hundred and sixty-five patients with perimenopausal insomnia were selected from our hospital during Jan. 2015-Mar. 2016, and then divided into group A (n=41), group B (n=41), group C (n=41) and group D (n=42) according to random number table. Group A was given Estazolam tablet 1 mg, qd; group B was given Jin’s three-needle 30 min/time, qd; group C was given Jiawei wumei pill, one pill, after breakfast and supper warm taking; group D was given Jin’s three-needle combined with Jiawei wumei pill with same usage as group C. Four groups were treated for 4 weeks. PSQI score, modified Kupperman score, life quality score, serum levels of E2 and FSH were observed in 4 groups before and after treatment, and the occurrence of ADR was recorded. RESULTS: Before treatment, there was no statistical significance in above score (P>0.05). After treatment, PSQI score and modified Kupperman score of 4 groups were decreased significantly, compared to before treatment; the group B, C, D were significantly lower than the group A; the group D was significantly lower the group B, C, with statistical significance (P<0.05). The life quality score of 4 groups were increased significantly, and the group B, C, D were significantly higher than the group A; the group D was significantly higher than the group B, C, with statistical significance (P<0.05). E2 level of group B, C, D were significantly increased, while FSH level was decreased significantly, the improvement of group D was significantly better than group B, C; the improvement of group D was significantly better than that of group B, C, with statistical significance (P<0.05). The incidence of ADR in group A was significantly higher than group B, C, D, with statistical significance (P<0.01), and there was no statistical significance in the incidence of ADR among group B, C, D, with statistical significance (P>0.05). CONCLUSIONS: Jin’s three needle combined with Jiawei wumei pill is effective in the treatment of perimenopausal insomnia with good safety. |
期刊: | 2017年第28卷第8期 |
作者: | 杜津莉,樊炜骏,杜洪娟 |
AUTHORS: | DU Jinli,FAN Weijun,DU Hongjuan |
关键字: | 靳三针;加味乌梅丸;艾司唑伦;失眠;围绝经期;生活质量 |
KEYWORDS: | Jin’s three needle; Jiawei wumei pill; Estazolam; Insomnia; Perimenopause; Life quality |
阅读数: | 326 次 |
本月下载数: | 3 次 |
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