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靳三针结合加味乌梅丸治疗围绝经期失眠的临床观察
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| 篇名： | 靳三针结合加味乌梅丸治疗围绝经期失眠的临床观察 |
| TITLE： | |
| 摘要： | 目的：观察靳三针联合加味乌梅丸治疗围绝经期失眠的效果及安全性。方法：选取我院2015年10月－2016年3月就诊的围绝经期失眠患者165例。按照随机数字表法分为A组（n＝41）、B组（n＝41）、C组（n＝41）和D组（n＝42）。A组患者给予艾司唑仑片1 mg，qd；B组患者采用靳三针疗法30 min/次，qd；C组患者给予加味乌梅丸1丸，于早晚餐后温服；D组患者采用靳三针结合加味乌梅丸治疗（方法同B、C组）。4组患者均治疗4周。观察4组患者治疗前后的匹茨堡睡眠质量指数量表（PSQI）评分、改良Kupperman评分、生活质量评分，血清雌二醇（E2）、卵泡刺激素（FSH）水平，并记录不良反应发生情况。结果：治疗前，上述评分和指标比较，差异均无统计学意义（P＞0.05）。治疗后，4组患者PSQI评分、改良Kupperman评分均较治疗前明显降低，且B、C、D组患者明显低于A组，D组患者明显低于B、C组，差异均有统计学意义（P＜0.05）；4组患者生活质量评分均较治疗前明显升高，且B、C、D组患者明显高于A组，D组患者明显高于B、C组，差异均有统计学意义（P＜0.05）；B、C、D组患者的E2水平均较治疗前及A组同期明显升高，FSH水平明显降低，且D组患者改善程度明显优于B、C组，差异均有统计学意义（P＜0.05）。A组患者不良反应发生率明显高于B、C、D组，差异有显著统计学意义（P＜0.01）；但B、C、D组患者不良反应发生率比较，差异无统计学差异（P＞0.05）。结论：靳三针结合加味乌梅丸治疗围绝经期失眠患者效果较好，且安全性高。 |
| ABSTRACT： | OBJECTIVE： To observe the effectiveness and safety of Jin’s three-needle combined with Jiawei wumei pill in the treatment of menopausal insomnia. METHODS： One hundred and sixty-five patients with perimenopausal insomnia were selected from our hospital during Jan. 2015-Mar. 2016， and then divided into group A （n＝41）， group B （n＝41）， group C （n＝41） and group D （n＝42） according to random number table. Group A was given Estazolam tablet 1 mg， qd； group B was given Jin’s three-needle 30 min/time， qd； group C was given Jiawei wumei pill， one pill， after breakfast and supper warm taking； group D was given Jin’s three-needle combined with Jiawei wumei pill with same usage as group C. Four groups were treated for 4 weeks. PSQI score， modified Kupperman score， life quality score， serum levels of E2 and FSH were observed in 4 groups before and after treatment， and the occurrence of ADR was recorded. RESULTS： Before treatment， there was no statistical significance in above score （P＞0.05）. After treatment， PSQI score and modified Kupperman score of 4 groups were decreased significantly， compared to before treatment； the group B， C， D were significantly lower than the group A； the group D was significantly lower the group B， C， with statistical significance （P＜0.05）. The life quality score of 4 groups were increased significantly， and the group B， C， D were significantly higher than the group A； the group D was significantly higher than the group B， C， with statistical significance （P＜0.05）. E2 level of group B， C， D were significantly increased， while FSH level was decreased significantly， the improvement of group D was significantly better than group B， C； the improvement of group D was significantly better than that of group B， C， with statistical significance （P＜0.05）. The incidence of ADR in group A was significantly higher than group B， C， D， with statistical significance （P＜0.01）， and there was no statistical significance in the incidence of ADR among group B， C， D， with statistical significance （P＞0.05）. CONCLUSIONS： Jin’s three needle combined with Jiawei wumei pill is effective in the treatment of perimenopausal insomnia with good safety. |
| 期刊： | 2017年第28卷第8期 |
| 作者： | 杜津莉，樊炜骏，杜洪娟 |
| AUTHORS： | DU Jinli，FAN Weijun，DU Hongjuan |
| 关键字： | 靳三针；加味乌梅丸；艾司唑伦；失眠；围绝经期；生活质量 |
| KEYWORDS： | Jin’s three needle； Jiawei wumei pill； Estazolam； Insomnia； Perimenopause； Life quality |
| 阅读数： | 341 次 |
| 本月下载数： | 3 次 |
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