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前列欣联合盐酸坦索罗辛和非那雄胺治疗老年良性前列腺增生的疗效观察
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| 篇名： | 前列欣联合盐酸坦索罗辛和非那雄胺治疗老年良性前列腺增生的疗效观察 |
| TITLE： | |
| 摘要： | 目的：观察前列欣联合盐酸坦索罗辛和非那雄胺治疗老年良性前列腺增生的临床疗效。方法：选择2012年5月－2014年10月我院确诊为良性前列腺增生的老年患者94例，根据入院单双号分为观察组（48例）和对照组（46例）。两组患者均给予非那雄胺片5 mg，po，qd，对照组患者在此基础上加用盐酸坦索罗辛缓释胶囊0.2 mg，po，qd；观察组患者在对照组基础上加用前列欣胶囊2.5 g，po，tid。两组患者均连续治疗3个月。观察两组患者临床疗效及治疗前后国际前列腺症状量表（IPSS）评分、泌尿症状困扰评分（BS）、勃起功能国际问卷（IIEF-5）评分、超声测量指标和中医证候评分。结果：观察组患者临床总有效率为93.75％，显著高于对照组的76.09％，差异有统计学意义（P＜0.05）。治疗前，两组患者IPSS、BS、IIEF-5评分及超声测量指标、中医证候评分比较，差异均无统计学意义（P＞0.05）；治疗后，两组患者IPSS、BS、前列腺体积（PV）、残余尿量（RU）、中医证候各项评分及总分均显著降低，IIEF-5评分、最大尿流率（Qmax）显著升高，且观察组明显优于对照组，差异均有统计学意义（P＜0.05）。结论：前列欣联合盐酸坦索罗辛和非那雄胺治疗老年良性前列腺增生疗效显著，有助于改善良性前列腺增生老年患者的前列腺症状和中医证候，减小PV和RU，改善性功能。 |
| ABSTRACT： | OBJECTIVE： To observe the clinical efficacy of qianliexin combined with tamsulosin hydrochloride and finasteride in the treatment of elderly benign prostatic hyperplasia. METHODS： Ninety-four patients diagnosed as benign prostatic hyperplasia in our hospital during May. 2012-Oct. 2014 were selected and divided into observation group （48 cases） and control group （46 cases） according to even and odd admission number. Both groups received Finasteride tablet 5 mg， po， qd. Basedon this， control group was additionally given Tamsulosin hydrochloride sustained-release capsules 0.2 mg， po， qd； observation group was additionally given Qianliexin capsules 2.5 g， po， tid， on the basis of control group. Clinical efficacies of 2 groups were observed as well as IPSS， BS， IIEF-5 score， ultrasonic measurement indexes and TCM syndrome score before and after treatment. RESULTS： Clinical total response rate of observation group was 93.75％， which was significantly higher than 76.09％ of control group， with statistical significance （P＜0.05）. Before treatment， there was no statistical significance in IPSS， BS， IIEF-5 score， ultrasonic measurement indexes and TCM syndrome score between 2 groups （P＞0.05）. After treatment， IPSS and BS score， prostate volume （PV）， residual urine（RU）， each item score and total score of TCM syndrome were significantly decreased in 2 groups， while IIEF-5 score and Qmax were increased significantly； the observation group was significantly better than the control group， with statistical significance（P＜0.05）. CONCLUSIONS： Qianliexin combined with tamsulosin hydrochloride and finasteride shows significant therapeutic efficacy for elderly benign prostatic hyperplasia， and is helpful to improve prostate symptoms and TCM syndromes， reduce PV and RU， and improve sexual function. |
| 期刊： | 2017年第28卷第8期 |
| 作者： | 王春仙，宫香宇，张素英，刘亚玮 |
| AUTHORS： | WANG Chunxian，GONG Xiangyu，ZHANG Suying，LIU Yawei |
| 关键字： | 良性前列腺增生；前列欣胶囊；盐酸坦索罗辛；非那雄胺；前列腺症状；中医证候；超声指标；老年 |
| KEYWORDS： | Benign prostatic hyperplasia； Qianliexin capsules； Tamsulosin hydrochloride； Finasteride； Prostate symptoms； TCM syndrome； Ultrasonic indicators； Elderly |
| 阅读数： | 666 次 |
| 本月下载数： | 2 次 |
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