我院丙氨酰谷氨酰胺合理使用评价标准的制订及干预效果分析
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篇名: 我院丙氨酰谷氨酰胺合理使用评价标准的制订及干预效果分析
TITLE:
摘要: 目的:探讨临床药师对丙氨酰谷氨酰胺注射液合理使用的干预效果。方法:参考丙氨酰谷氨酰胺注射液说明书、《肠外营养临床药学共识》、美国肠外肠内营养学会《危重症患者营养治疗指南》和相关文献等制订丙氨酰谷氨酰胺注射液合理使用评价标准;调取我院2015年第二季度全部病例10 789例中使用丙氨酰谷氨酰胺注射液病例(497例)和2016年第二季度全部病例13 283例中使用丙氨酰谷氨酰胺注射液病例(385例)进行专项点评,比较和分析干预前后该药合理使用情况。结果:干预前,丙氨酰谷氨酰胺注射液使用率为4.6%,不合理率为52.9%;干预后,使用率为2.9%,不合理率为10.9%,差异有统计学意义(P<0.05)。干预后,在超适应证、药液浓度过高、氨基酸供给超标、溶剂选择不合理、存在配伍和疗程过长等方面与干预前比较,差异均有统计学意义(P<0.05)。结论:临床药师通过制订丙氨酰谷氨酰胺注射液合理使用评价标准,并对丙氨酰谷氨酰胺注射液的合理使用进行药学干预,降低了不合理使用率,保障了临床用药的安全、有效。
ABSTRACT: OBJECTIVE: To explore the effect of clinical pharmacist intervention on the rational use of Alanyl-glutamine injection. METHODS: Referring to package inserts of Alanyl-glutamine injection, Clinical Pharmacy Consensus of Parenteral Nutrition, ASPEN Nutrition Therapy Guidelines for Critically Ill Patients, related domestic and foreign literatures, evaluation criteria for Alanyl-glutamine injection rational use was formulated. After collecting Alanyl-glutamine injection cases (497 cases) in the second quarter of 2015 and those cases (385 cases) in the second quarter of 2016, rational use of Alanyl-glutamine injection were analyzed comparatively before and after intervention. RESULTS: The utilization rate and irrational rate of Alanyl-glutamine injection were 4.6% and 52.9% before intervention as well as 2.9% and 10.9% after intervention, with statistical significance (P<0.05). There was statistical significance in hyper-indication, excessive concentration of drug liquid, excessive supply of amino acid, irrational compatibility and solvent selection, long treatment course before and after intervention (P<0.05).  CONCLUSIONS: Clinical pharmacists reduce irrational rate of drug use and guarantee safe and effective drug use through formulating evaluation criteria for Alanyl-glutamine injection rational use and providing pharmaceutical intervention on rational use of Alanyl-glutamine injection.
期刊: 2017年第28卷第8期
作者: 陈枳潓,刘可欣,梁茂植
AUTHORS: CHEN Zhihui,LIU Kexin,LIANG Maozhi
关键字: 丙氨酰谷氨酰胺;药学干预;合理使用;干预效果
KEYWORDS: Alanyl-glutamine; Pharmaceutical intervention; Rational use; Intervention effect
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