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肾福康胶囊治疗肾功能不全的临床研究
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| 篇名： | 肾福康胶囊治疗肾功能不全的临床研究 |
| TITLE： | |
| 摘要： | 目的：探讨肾福康胶囊治疗肾功能不全患者的临床疗效及对肾功能指标的影响。方法：对广西医科大学第一附属医院2015年2－5月使用肾福康胶囊治疗肾功能不全的住院患者100例进行回顾性分析，记录患者一般情况、治疗方案、治疗前后的肾功能指标和临床疗效，并分析临床疗效与年龄、疗程的关系。结果：急性肾功能不全33例，慢性肾功能不全67例。肾福康胶囊的给药方式主要是口服给药（97例，97.00％），剂量主要为6粒/d（36例，36.00％），疗程以0～＜7 d（39例）和7～＜15 d（49例）为主。治疗后，所有患者的血清肌酐水平较治疗前显著降低，肾小球滤过率、内生肌酐清除率较治疗前显著升高，差异有统计学意义（P＜0.05）。患者总有效率为72.00％，其中急性肾功能不全患者有效率为87.88％，显著高于慢性肾功能不全患者的64.18％，差异有统计学意义（P＜0.05）。≤60岁患者中，急性肾功能不全患者的总有效率显著高于慢性肾功能不全患者，差异有统计学意义（P＜0.05）；＞60岁急、慢性肾功能不全患者疗效比较，差异无统计学意义（P＞0.05）；慢性肾功能不全患者中，＞60岁患者的总有效率显著高于≤60岁患者，差异有统计学意义（P＜0.05）。随着疗程延长，急性肾功能不全患者的总有效率呈上升趋势，慢性肾功能不全患者的总有效率先升高后下降。所有患者治疗期间均未见明显不良反应的发生。结论：肾福康胶囊可改善肾功能不全患者的肾功能，对急性肾功能不全患者临床疗效优于慢性肾功能不全患者，且安全性好；其临床疗效可能与年龄、疗程有关。 |
| ABSTRACT： | OBJECTIVE： To investigate the effects of Shenfukang capsules on clinical efficacy and renal function indexes of patients with renal insufficiency. METHODS： Totally 100 inpatients with renal insufficiency treated by Shenfukang capsules in the First Affiliated Hospital of Guangxi Medical University during Feb. to Mar. 2015 were analyzed retrospectively in respects of general information of patients， therapy plan， renal function indexs before and after treatment and clinical efficacy. The relationship of clinical efficacy with age and duration was also analyzed. RESULTS： There were 33 cases of acute renal insufficiency and 67 cases of chronic renal insufficiency. The route of administration of Shenfukang capsules was oral administration （97 cases， 97.00％）， the main dosage was 6 capsule/d （36 cases， 36.00％）， and treatment duration were 0-＜7 days （39 cases） and 7-＜15 days （49 cases）. After treatment， the average serum creatinine concentration was lower than before treatment， while mean GFR and Ccr were higher than before treatment， with statistical significance （P＜0.05）. The total response rate was 72.00％， and response rate of patients with acute renal insufficiency was 87.88％ and significantly higher than 64.18％ of patients with chronic renal insufficiency， with statistical significance（P＜0.05）. Among patients with ≤60 years old， the total response rate of patients with acute renal insufficiency was significantly higher than that of patients with chronic renal insufficiency， with statistical significance（P＜0.05）； among patients elder than 60 years old， there was no statistical significance in therapeutic efficacy between acute renal insufficiency and chronic renal insufficiency （P＞0.05）； among patients with chronic renal insufficiency， the total response rate of patients elder than 60 years old was significantly better than that of patients with ≤60 years old， with statistical significance （P＜0.05）. With the extension of treatment duration， the total response rate of patients with acute renal insufficiency was on the rise， and that of patients with chronic renal insufficiency increased first and then decreased. No obvious ADR was found during treatment. CONCLUSIONS： Shenfukang capsules can improve renal function in patients with renal insufficiency， and has definite curative effect on acute and chronic renal insufficiency with good security. The clinical efficacy may be related to age and treatment course. |
| 期刊： | 2017年第28卷第14期 |
| 作者： | 蔡果珍，钟小斌，杨玉芳，邹小琴，农秋萍，陆斯斯，梁雪艳 |
| AUTHORS： | CAI Guozhen，ZHONG Xiaobin，YANG Yufang，ZOU Xiaoqin，NONG Qiuping，LU Sisi，LIANG Xueyan |
| 关键字： | 肾福康胶囊；肾功能不全；疗效分析；合理用药 |
| KEYWORDS： | Shenfukang capsules； Renal insufficiency； Therapeutic efficacy analysis； Rational use of drug |
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