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康复新液联合重组人表皮生长因子外用溶液治疗维生素B12缺乏型萎缩性舌炎的临床观察
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| 篇名： | 康复新液联合重组人表皮生长因子外用溶液治疗维生素B12缺乏型萎缩性舌炎的临床观察 |
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| 摘要： | 目的：观察康复新液联合重组人表皮生长因子（rhEGF）外用溶液治疗维生素B12缺乏型萎缩性舌炎的临床疗效及安全性。方法：将2012年7月－2015年6月于新疆生产建设兵团医院接受治疗的94例维生素B12缺乏型萎缩性舌炎患者按随机数字表法分为观察组和对照组，各47例。两组患者均给予补充维生素B12等对因治疗；对照组患者加用rhEGF外用溶液喷洒于舌表面，qid；观察组患者在对照组治疗基础上加用康复新液，将药液浸透于医用纱布上贴敷于患处，每次贴敷30 min以上，tid。两组疗程均为4周，每周复诊1次。比较两组患者的临床疗效、治疗前后的平均疼痛指数和舌部病损面积，以及不良反应发生情况。结果：观察组患者的治愈率（76.6％ vs. 57.4％）和总有效率（97.9％ vs. 83.0％）均明显高于对照组，差异均有统计学意义（P＜0.05）。治疗前，两组患者的平均疼痛指数和舌部病损面积比较，差异均无统计学意义（P＞0.05）；治疗后1～4周，两组患者的平均疼痛指数明显降低，舌部病损面积均明显减小，与治疗前比较差异均有统计学意义（P＜0.05）；且观察组患者的平均疼痛指数明显低于对照组（治疗后3、4周），舌部病损面积明显小于对照组（治疗后2～4周），差异均有统计学意义（P＜0.05）。两组患者均未见明显不良反应发生。结论：康复新液联合rhEGF外用溶液治疗维生素B12缺乏型萎缩性舌炎能明显改善患者舌部病损情况，并具有较好的镇痛效应和安全性。 |
| ABSTRACT： | OBJECTIVE： To observe the clinical efficacy and safety of Kangfuxin solution combined with rhEGF solution for external use in the treatment of vitamin B12 deficiency atrophic glossitis. METHODS： Totally 94 patients with vitamin B12 deficiency atrophic glossitis in Xinjiang Production and Construction Corps Hospital during Jul. 2012-Jun. 2015 were divided into observation group and control group according to random number table， with 47 cases in each group. Both groups received etiological treatment of vitamin B12 supplement. Control group was additionally given rhEGF solution for external use on tongue surface， qid. Based on control group， observation group was additionally given Kangfuxin solution and applied medical gauze saturated with liquid medicine to the affected area， more than 30 min each time， tid. Treatment course of 2 groups lasted for 4 week， a referral of the week. Clinical efficacies were compared between 2 groups as well as average pain indexes and lesion areas of tongue before and after treatment， and the occurrence of ADR. RESULTS： Cure rate （76.6％ vs. 57.4％） and total response rate （97.9％ vs. 83.0％） of observation group were significantly higher than those of control group， with statistical significance （P＜0.05）. Before treatment， there was no statistical significance in average pain indexes and lesion areas of tongue between 2 groups （P＞0.05）. 1-4 weeks after treatment， average pain indexes and lesion areas of tongue in 2 groups were significantly decreased， with statistical significance compared to before treatment （P＜0.05）. The average pain indexes of observation group were significantly lower than those of control group （3，4 weeks after treatment）， and lesion areas of tongue was significantly smaller than control group （2-4 weeks after treatment）， with statistical significance （P＜0.05）. No obvious ADR was found in 2 groups. CONCLUSIONS： For vitamin B12 deficiency atrophic glossitis， Kangfuxin solution combined with rhEGF solution for external use can significantly improve tongue lesion and have good analgesic effect and safety. |
| 期刊： | 2017年第28卷第14期 |
| 作者： | 张澜，张玉玲，刘鑫 |
| AUTHORS： | ZHANG Lan，ZHANG Yuling，LIU Xin |
| 关键字： | 维生素B12；萎缩性舌炎；康复新液；重组人表皮生长因子外用溶液 |
| KEYWORDS： | Vitamin B12； Atrophic glossitis； Kangfuxin solution； rhEGF solution for external use |
| 阅读数： | 1486 次 |
| 本月下载数： | 1 次 |
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