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天芪降糖胶囊联合二甲双胍治疗老年2型糖尿病伴脑微血管病变的临床观察
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| 篇名： | 天芪降糖胶囊联合二甲双胍治疗老年2型糖尿病伴脑微血管病变的临床观察 |
| TITLE： | |
| 摘要： | 目的：观察天芪降糖胶囊联合二甲双胍治疗老年2型糖尿病伴脑微血管病变的疗效和安全性。方法： 96例老年2型糖尿病伴脑微血管病变患者随机分为对照组（48例）和观察组（48例）。对照组患者给予盐酸二甲双胍片0.5 g，口服，每日3次；观察组患者在对照组治疗的基础上给予天芪降糖胶囊1.6 g，口服，每日3次。两组均用药4周。观察两组患者的临床疗效，治疗前后中医证候总积分、血糖水平[空腹血糖（FPG）、餐后2 h血糖（2 hPG）、糖化血红蛋白（HbA1c）]、血脂水平[总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）]、超敏C反应蛋白（hs-CRP）和内皮素-1（ET-1）水平、血液流变学指标、氧化应激指标[丙二醛（MDA）、超氧化物歧化酶（SOD）]及不良反应发生情况。结果：观察组患者总有效率显著高于对照组（89.58％ vs. 70.83％），差异有统计学意义（P＜0.05）。治疗后，两组患者中医证候总积分和血糖、hs-CRP、ET-1、TC、TG、LDL-C、血液流变学指标、MDA水平均显著低于同组治疗前，且观察组中医证候总积分、FPG、2 hPG、hs-CRP、ET-1、TC、TG、LDL-C、血液流变学指标、MDA水平均显著低于对照组；两组患者SOD水平均显著高于同组治疗前，且观察组显著高于对照组，同时观察组 HDL-C水平显著高于同组治疗前及对照组，差异均有统计学意义（P＜0.05）。两组患者治疗期间均未见明显不良反应发生。结论：天芪降糖胶囊联合二甲双胍治疗老年2型糖尿病伴脑微血管病变的疗效显著，可降低血糖、血脂水平，改善机体血液流变学状态及氧化应激反应，且安全性较好。 |
| ABSTRACT： | OBJECTIVE： To observe clinical efficacy and safety of Tianqi jiangtang capsules combined with metformin in the treatment of elderly patients with type 2 diabetes mellitus complicated with cerebral microvascular lesions. METHODS： A total of 96 elderly patients with type 2 diabetes mellitus complicated with cerebral microvascular lesions were randomly divided into control group （48 cases） and observation group （48 cases）. Control group was given Metformin hydrochloride tablets 0.5 g orally， 3 times a day. Observation group was additionally given Tianqi jiangtang capsules 1.6 g orally， 3 times a day， on the basis of control group. Both groups received treatment for 4 weeks. Clinical efficacies of 2 groups were observed as well as total score of TCM symptoms， the levels of blood glucose （FPG， 2 hPG， HbA1c）， blood lipid （TC， TG， HDL-C， LDL-C），hs-CRP， ET-1， blood rheology and oxidative stress indexes （MDA， SOD）， the occurrence of ADR. RESULTS： The total response rate of observation group was significantly higher than that of control group（89.58％ vs. 70.83％）， with statistical significance （P＜0.05）. After treatment， total score of TCM symptoms， the levels of blood glucose， hs-CRP， ET-1， TC， TG， LDL-C， blood rheology indexes and MDA in 2 groups were significantly lower than before； total score of TCM symptoms， the levels of FPG， 2 hPG， hs-CRP， ET-1， TC， TG， LDL-C， blood rheology indexes and MDA in observation group were significantly lower than control group； the level of SOD in 2 groups were significantly higher than before， and the observation group was significantly higher than control group， and the level of HDL-C in observation group was significantly higher than before treatment and control group， with statistical significance （P＜0.05）. No obvious ADR was found in 2 groups during treatment. CONCLUSIONS： Tianqi jiangtang capsules combined with metformin show significant therapeutic efficacy in the treatment of elderly patients with type 2 diabetes mellitus， and can reduce the levels of blood glucose and lipid， improve blood rheology and oxidative stress reaction， with goud safety. |
| 期刊： | 2017年第28卷第15期 |
| 作者： | 柴红，路一芳，肖红珍，李颖，崔坤，张援月 |
| AUTHORS： | CHAI Hong，LU Yifang，XIAO Hongzhen，LI Ying，CUI Kun，ZHANG Yuanyue |
| 关键字： | 2型糖尿病；脑微血管病变；天芪降糖胶囊；二甲双胍；疗效；安全性 |
| KEYWORDS： | Type 2 diabetes mellitus； Cerebral microvascular lesions； Tianqi jiangtang capsules； Metformin； Efficacy； Safety |
| 阅读数： | 384 次 |
| 本月下载数： | 5 次 |
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