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咪达唑仑联合曲马多对实施胃肠外科肿瘤切除术患者预后的影响
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| 篇名： | 咪达唑仑联合曲马多对实施胃肠外科肿瘤切除术患者预后的影响 |
| TITLE： | |
| 摘要： | 目的：探讨咪达唑仑联合曲马多对实施胃肠外科肿瘤切除术患者预后的影响。方法：回顾性分析200例胃肠外科肿瘤患者资料，按用药的不同分为观察组（100例）和对照组（100例）。观察组患者给予盐酸曲马多片100 mg，每日3次+咪达唑仑注射液30 mg，加入0.9％氯化钠注射液60 mL中静脉泵注，2.5 mL/h，连续泵注24 h，持续3 d；对照组患者给予盐酸曲马多注射液100 mg，肌内注射，每日3次，连用3 d。观察两组患者住院时间、术后下床时间、睡眠质量评分、疼痛程度评分、术后坠积性肺炎发生率及不良反应发生情况。结果：观察组患者住院时间、术后下床时间均显著短于对照组，睡眠质量评分显著高于对照组，疼痛程度评分、术后坠积性肺炎发生率均显著低于对照组，差异均有统计学意义（P＜0.05）。两组患者不良反应发生率比较，差异无统计学意义（P＞0.05）。结论：咪达唑仑联合曲马多可显著减轻胃肠外科肿瘤患者术后疼痛，缩短住院时间及术后下床时间，提高睡眠质量，降低坠积性肺炎发生率，且安全性较好。 |
| ABSTRACT： | OBJECTIVE： To investigate the effects of tramadol combined with midazolam on prognosis of patients underwent tumor resection in gastrointestinal surgery department. METHODS： In retrospective study， 200 tumor patients of gastrointestinal surgery department were divided into observation group （100 cases） and control group （100 cases）. Observation group was given Tramadol hydrochloride tablet 100 mg， 3 times a day+Midazolam injection 30 mg， added into 0.9％ Sodium chloride injection 60 mL， via intravenous pump， 2.5 mL/h， for consecutive 24 h， for consecutive 3 d. Control group was given Tramadol hydrochloride injection 100 mg， intramuscular injection， 3 times a day， for 3 d. The hospitalization duration， postoperative ambulation time， sleep quality score， pain degree score， the occurrence of postoperative hypostatic pneumonia，and the incidence of adverse reactions in 2 groups were observed. RESULTS： The hospitalization duration and postoperative ambulation time of observation group were significantly shorter than those of control group； the sleep quality score of observation groups was significantly higher than that of control group； the severity of pain， the incidence of hypostatic pneumonia were significantly lower than control group， with statistical significance （P＜0.05）. There was no statistical significance in the incidence of ADR between 2 groups （P＞0.05）. CONCLUSIONS： Midazolam combined with tramadol can significantly reduce the postoperative pain of tumor patients in gastrointestinal tumor surgery department， shorten hospitalization time and postoperative ambulation time， improve the sleep quality of patients and reduce the incidence of hypostatic pneumonia with good safety. |
| 期刊： | 2017年第28卷第15期 |
| 作者： | 张德重，王丽丽 |
| AUTHORS： | ZHANG Dezhong，WANG Lili |
| 关键字： | 咪达唑仑；曲马多；术后康复；胃肠外科；肿瘤；坠积性肺炎 |
| KEYWORDS： | Midazolam； Tramadol； Postoperative rehabilitation； Gastrointestinal surgery department； Tumor； Hypostatic pneumonia |
| 阅读数： | 405 次 |
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