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启宫丸汤联合化学药对多囊卵巢综合征合并不孕症患者血清激素水平的影响
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| 篇名： | 启宫丸汤联合化学药对多囊卵巢综合征合并不孕症患者血清激素水平的影响 |
| TITLE： | |
| 摘要： | 目的：探讨启宫丸汤联合化学药对多囊卵巢综合征（PCOS）合并不孕症患者激素水平的影响。方法：选取2015年7月－2016年6月于我院妇科就诊的PCOS合并不孕症患者98例为研究对象，采用随机数字表法分为观察组和对照组，各49例。对照组患者于月经第5天起口服枸橼酸氯米芬片50 mg，qd，连续5 d；于月经第11天行B超监测卵泡发育情况，若无直径＞10 mm的优势卵泡则肌内注射注射用绒促性素2 000 U，隔日1次，至卵泡发育直径达18 mm。观察组患者在对照组基础上加用启宫丸汤，每日1剂，水煎取汁400 mL，早晚各服200 mL。治疗3个月后，比较两组患者血清卵泡刺激素（FSH）、黄体生成素（LH）、泌乳素（PRL）、雌二醇（E2）、总睾酮（T）、硫酸脱氢表雄酮（DHEA-S）、性激素结合球蛋白（SHBG）水平，以及子宫内膜厚度、成熟卵泡数量和妊娠率。结果：治疗前，两组患者FSH、LH、PRL、E2、T、DHEA-S、SHBG水平比较，差异均无统计学意义（P＞0.05）。治疗3个月后，两组患者PRL、T、DHEA-S水平显著降低，E2、EHBG水平显著升高；且观察组患者FSH、PRL、T、DHEA-S水平显著低于对照组，E2、SHBG水平显著高于对照组，差异均有统计学意义（P＜0.05）。观察组患者子宫内膜厚度明显大于对照组，妊娠率（18.37％）明显高于对照组（4.08％），差异均有统计学意义（P＜0.05）。结论：启宫丸汤联合化学药治疗PCOS合并不孕症，有助于调节患者血清激素水平、提高妊娠率。 |
| ABSTRACT： | OBJECTIVE： To investigate the effects of Qigong pills decoction combined with chemical drugs on hormone levels of polycystic ovarian syndrome （PCOS） patients complicated with infertility. METHODS： A total of 98 PCOS patients complicated with infertility selected from gynaecology department of our hospital during Jul. 2015-Jun. 2016 were divided into observation group and control group according to random number table， with 49 cases in each group. Control group was given Clomiphene citrate tablet 50 mg orally， qd， for consecutive 5 d； B-ultrasonography for follicle development was monitored at the 11th day of menstruation， and then they were given Chorionic Gonadotropin for injection 2 000 U intramuscularly， qod， if there was not dominant follicle ＞10 mm till the diameter of follicle reached 18 mm. Observation group was additionally given one dose of Qigong pills decoction， every day 400 mL after decocted with water， each 200 mL for morning and night， on the basis of control group. After 3 months of treatment， the levels of FSH， LH， PRL， E2， T， DHEA-S and SHBG， the endometrial thickness， the number of mature follicle and pregnancy rate were compared between 2 groups. RESULTS： Before treatment， there was no statistical significance in the levels of FSH， LH， PRL， E2， T， DHEA-S or SHBG between 2 groups （P＞0.05）. 3 months after treatment， the levels of PRL， T and DHEA-S in 2 groups were decreased and E2， SHBG were increased significantly； the levels of FSH， PRL， T and DHEA-S in observation group were significantly lower than control group， while the levels of E2 and SHBG were significantly higher than control group， with statistical significance （P＜0.05）. Endometrial thickness of observation group were significantly higher than that of control group； pregnancy rate （18.37％） was significantly higher than control group （4.08％）， with statistical significance （P＜0.05）. CONCLUSIONS： Qigong pills decoction combined with chemical drugs can help to improve pregnancy rate and regulate serum hormone level in the treatment of PCOS complicated with infertility. |
| 期刊： | 2017年第28卷第17期 |
| 作者： | 赵凤英，赵惠芬，马梅，徐艳 |
| AUTHORS： | ZHAO Fengying，ZHAO Huifen，MA Mei，XU Yan |
| 关键字： | 多囊卵巢综合征；不孕症；启宫丸汤；血清激素水平；妊娠率 |
| KEYWORDS： | Polycystic ovarian syndrome； Infertility； Qigong pills decoction； Serum hormone levels； Pregnancy rate |
| 阅读数： | 348 次 |
| 本月下载数： | 3 次 |
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