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血必净注射液治疗Ⅲ～Ⅳ期压疮伴中重度感染的临床观察
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| 篇名： | 血必净注射液治疗Ⅲ～Ⅳ期压疮伴中重度感染的临床观察 |
| TITLE： | |
| 摘要： | 目的：观察血必净注射液辅助治疗Ⅲ～Ⅳ期压疮伴中重度感染的临床效果及安全性。方法：选取2011年7月－2016年6月在我院治疗的Ⅲ～Ⅳ期压疮伴中重度感染患者130例，按随机数字表法分为对照组和观察组，各65例。对照组患者经冲洗后使用0.5％碘伏消毒液消毒疮面，再用0.5％碘伏消毒液将无菌纱布浸湿后湿敷疮面30 min，然后用爱康肤吸收性银离子抗菌愈合敷料填充伤口，敷料被渗液湿透2/3时换药。观察组患者在对照组治疗基础上，加用血必净注射液50 mL加入生理盐水100 mL中静脉滴注30～40 min，2～3次/d，连用7 d。两组患者疗程均为4周。比较两组患者的临床疗效、压疮愈合评分表（PUSH）评分、清创时间、局部症状消退时间、全身炎症反应综合征（SIRS）消退时间，以及不良反应发生情况。结果：观察组患者的总有效率（93.85％）明显高于对照组（80.00％），清创时间、局部症状和SIRS消退时间均明显短于对照组，差异均有统计学意义（P＜0.05）。治疗前，两组患者的PUSH评分比较，差异均无统计学意义（P＞0.05）；治疗1～4周后，两组患者的PUSH评分均较治疗前明显下降，且观察组明显低于同期对照组，差异均有统计学意义（P＜0.05）。两组患者均未见明显不良反应发生。结论：血必净注射液治疗Ⅲ～Ⅳ期压疮伴中重度感染能够有效减少炎性渗出、促进疮面坏死组织吸收、缓解局部症状和全身炎症反应、加快病变部位修复，具有较好的临床疗效和较高的安全性。 |
| ABSTRACT： | OBJECTIVE： To observe the clinical effect and safety of Xuebijing injection in the treatment of moderate and severe infection of stage Ⅲ-Ⅳ pressure ulcer. METHODS： A total of 130 cases of moderate and severe infection of stage Ⅲ-Ⅳ pressure ulcer admitted to our hospital from Jul. 2011 and Jun. 2016 were randomly divided into observation group and control group， with 65 cases in each group. Control group was treated with 0.5％ Iodophor disinfectant to disinfect the sore surface， given wet sterile gauze soaked with 0.5％ Iodophor disinfectant to compress sore surface for 30 min， and then given Aikangfu absorptive silver ion antibacterial healing dressing to fill wound， changed dressing after 2/3 was soaked. Observation group was additionally given Xuebijing injection 50 mL added into normal saline 100 mL intravenously for 30-40 min， 2-3 times a day， for consecutive 7 days， on the basis of control group. Treatment course of both groups lasted for 4 weeks. The clinical efficacy， the score of pressure ulcer scale for healing （PUSH）， debridement time， the time of local symptom and SIRS disappearance as well as the occurrence of ADR were compared between 2 groups. RESULTS： The total response rate of observation group （93.85％） was significantly higher than that of control group （80.00％）， and debridement time， the time of local symptom and SIRS disappearance were all significantly shorter than control group， with statistical significance （P＜0.05）. Before treatment， there was no statistical significance in PUSH score between 2 groups （P＞0.05）. After 1-4 weeks of treatment， PUSH score of 2 groups was decreased significantly compared to before treatment， and the score of observation group was significantly lower than that of control group， with statistical significance （P＜0.05）. No obvious ADR was found in 2 groups. CONCLUSIONS： For moderate and severe infection of stage Ⅲ-Ⅳ pressure ulcer， Xuebijing injection effectively reduces inflammatory exudation， improves the absorption of necrotic tissue， relieves local symptom and systematic inflammatory reaction， promotes the healing of pressure ulcers and has good clinical effect and safety. |
| 期刊： | 2017年第28卷第20期 |
| 作者： | 任少强，杨静，李大君，韩雷，徐祥 |
| AUTHORS： | REN Shaoqiang，YANG Jing，LI Dajun，HAN Lei，XU Xiang |
| 关键字： | 血必净注射液；压疮；中重度感染；碘伏消毒液；抗菌敷料 |
| KEYWORDS： | Xuebijing injection； Pressure ulcer； Moderate and severe infection； Zodophor disinfectant； Antibacterial dressing |
| 阅读数： | 897 次 |
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