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布地奈德联合沙丁胺醇治疗婴幼儿毛细支气管炎的临床观察
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| 篇名： | 布地奈德联合沙丁胺醇治疗婴幼儿毛细支气管炎的临床观察 |
| TITLE： | |
| 摘要： | 目的：探讨在沙丁胺醇基础上加用布地奈德治疗婴幼儿毛细支气管炎的疗效、安全性和经济性。方法：采用前瞻性研究方法，选择2014年10月－2016年4月我院毛细支气管炎的住院患儿160例。按入院号顺序，单号为观察组，双号为对照组，各80例。两组患儿均给予常规治疗。对照组患儿给予吸入用硫酸沙丁胺醇溶液0.25 mL加入0.9％氯化钠注射液3 mL，q8 h；观察组患儿给予吸入用布地奈德混悬液2 mL+吸入用硫酸沙丁胺醇溶液0.25 mL加入0.9％氯化钠注射液1 mL，q8 h；两组患儿均采用氧气驱动雾化吸入，均连续治疗5～7 d。观察两组患儿临床症状消失时间、住院时间、临床疗效，比较治疗药品（雾化吸入药品和其他治疗药品）费用，并记录不良反应发生情况。结果：两组患儿咳嗽消失时间、喘息消失时间、啰音消失时间、三凹征消失时间和住院时间比较，差异均无统计学意义（P＞0.05）；观察组患儿的临床总有效率（95.00％）与对照组（92.50％）比较，差异无统计学意义（P＞0.05）；观察组患儿雾化吸入药品费用[（355.77±10.98）元]明显高于对照组[（26.83±2.86）元]，差异有统计学意义（P＜0.05）；两组患儿常规治疗药品费用比较，差异无统计学意义（P＞0.05）；两组患儿治疗期间均未见明显不良反应发生。结论：在沙丁胺醇基础上雾化吸入布地奈德治疗婴幼儿毛细支气管炎并不能显著减轻病情、缩短住院时间和提高临床疗效，但增加了治疗费用。 |
| ABSTRACT： | OBJECTIVE： To investigate therapeutic efficacy， safety and economics of budesonide for infant bronchiolitis based on salbutamot. METHODS： In prospective study， 160 inpatient children with bronchiolitis during Oct. 2014-Apr. 2016 were divided into observation group and control group according to admission order， with 80 cases in each group. Both groups received conventional treatments. Control group was given Salbutamol solution for inhalation 0.25 mL added into 0.9％ Sodium chloride injection 3 mL， q8 h. Observation group was given Budesonide suspension for inhalation 2 mL added into 0.9％ Sodium chloride injection 1 mL+Salbutamol solution for inhalation 0.25 mL， q8 h. Both groups received oxygen driven inhalation， and treated for 5-7 d. Clinical symptom disappearance time， hospitalization time and clinical efficacy were compared between 2 groups as well as therapy drug cost （aerosol inhalation， other therapy drugs）. The occurrence of ADR was recorded. RESULTS： There was no statistical significance in cough disappearance time， wheezing disappearance time， lung rale disappearance time， tri-retraction sign disappearance time and hospitalization time between 2 groups （P＞0.05）. There was no statistical significance in total response rate between observation group （95.00％） and control group （92.50％） （P＞0.05）. The cost of inhalation drugs in observation group [（355.77±10.98）yuan] was significantly higher than control group [（26.83±2.86）yuan]， with statistical significance （P＜0.05）. There was no statistical significance in the cost of routine therapy drugs between 2 groups （P＞0.05）. There was no significant ADR between 2 groups during treatment. CONCLUSIONS： For infant bronchiolitis， aerosol inhalation of budesonide based on salbutamol sulfate can not significantly shorten disease， shorten hospitalization time and improve clinical efficacy， but increase therapy cost. |
| 期刊： | 2017年第28卷第20期 |
| 作者： | 杨丽，金英姬，张亚明 |
| AUTHORS： | YANG Li，JIN Yingji，ZHANG Yaming |
| 关键字： | 毛细支气管炎；布地奈德；沙丁胺醇；婴幼儿；雾化吸入；疗效；药品费用 |
| KEYWORDS： | Bronchiolitis； Budesonide； Salbutamol； Infant； Aerosol inhalation； Therapeutic efficacy； Drug cost |
| 阅读数： | 344 次 |
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