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丹红注射液联合低分子肝素对老年COPD患者的临床症状、血清炎症因子及肺功能的影响
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| 篇名： | 丹红注射液联合低分子肝素对老年COPD患者的临床症状、血清炎症因子及肺功能的影响 |
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| 摘要： | 目的：探讨丹红注射液联合低分子肝素对老年慢性阻塞性肺疾病（COPD）患者的临床症状、血清炎症因子及肺功能的影响。方法： 146例老年COPD患者随机分为观察组和对照组，每组73例。两组均给予常规治疗， 在此基础上对照组患者给予丹红注射液30 mL，静脉滴注，每天1次。观察组患者在对照组治疗基础上给予低分子肝素钠注射液5 000 IU，皮下注射，每天2次。两组疗程均为14 d。观察并比较两组患者临床疗效，治疗前后临床症状评分、白细胞介素6（ IL-6）、IL-8、肿瘤坏死因子α（TNF-α）、1秒用力呼吸容积（FEVl）、1秒呼出的气体量占肺内总量的百分比（FEVl/FVC）、动脉血氧分压[pa（O2）]、动脉血二氧化碳分压[pa（CO2）]和不良反应发生情况。结果：治疗后观察组患者总有效率显著高于对照组，差异有统计学意义（93.15％ vs. 78.08％，P＜0.05）。治疗前，上述各项指标比较，差异均无统计学意义（P＞0.05）。治疗后，两组患者各单项临床症状评分、临床症状总评分、IL-6、IL-8、TNF-α和pa（CO2）显著低于同组治疗前，且观察组显著低于对照组；两组患者FEVl、FEVl/FVC、pa（O2）显著高于同组治疗前，且观察组显著高于对照组，差异均有统计学意义（P＜0.05）。两组患者均未见明显不良反应发生。结论：在常规治疗基础上，丹红注射液联合低分子肝素治疗老年COPD疗效较好，可以显著改善患者临床症状、血清炎症因子水平和肺功能，安全性亦较好。 |
| ABSTRACT： | OBJECTIVE： To investigate the effects of Danhong injection combined with low molecular weight heparin （LMWH） on clinical symptoms， serum inflammatory factors and lung function in elderly patients with chronic obstructive pulmonary disease （COPD）. METHODS： A total of 146 elderly patients with COPD were randomly divided into observation group and control group， with 73 cases in each group. Both groups received conventional treatment. On this basis， control group was given Danhong injection 30 mL， intravenous drip， once a day. Observation group was additionally given LMWH sodium injection 5 000 IU， subcutaneously， twice a day， on the basis of control group. Both groups were treated for 14 d. Clinical efficacies of 2 groups were observed and compared. The clinical symptom score， the levels of IL-6， IL-8，TNF-α， FEV1， FEV1/FVC， pa（O2）， pa（CO2） and the occurrence of ADR were compared before and after treatment. RESULTS： After treatment， the total response rate of observation group was significantly higher than that of control group （93.15％ vs. 78.08％，P＜0.05）. Before treatment， there was no statistical significance between above indexes （P＞0.05）. After treatment， individual clinical symptom score， total clinical symptom score， the levels of IL-6， IL-8，TNF-α， pa（CO2） in 2 groups were significantly lower than before； the observation group was significantly lower than the control group； FEV1， FEVl/FVC， pa（O2） were significantly higher than before， and the observation group was significantly higher than the control group， with statistical significance （P＜0.05）. CONCLUSIONS： Based on conventional treatment， Danhong injection combined with LMWH is effective in the treatment of senile COPD， and can significantly improve the clinical symptoms， serum inflammatory factors levels and pulmonary function with good safety. |
| 期刊： | 2017年第28卷第21期 |
| 作者： | 黄园，李璐 |
| AUTHORS： | HUANG Yuan， LI Lu |
| 关键字： | 老年；慢性阻塞性肺疾病；丹红注射液；低分子肝素；炎症因子；肺功能 |
| KEYWORDS： | Elderly； Chronic obstructive pulmonary disease； Danhong injection； Low molecular weight heparin； Inflammatory factor； Lung function |
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