前列地尔注射液不同给药方式致静脉炎的系统评价
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篇名: | 前列地尔注射液不同给药方式致静脉炎的系统评价 |
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摘要: | 目的:系统评价前列地尔注射液不同给药方式致静脉炎发生情况的差异,为临床提供循证参考。方法:计算机检索PubMed、EMBase、Cochrane 图书馆、中国生物医学文献数据库、中国期刊全文数据库、中文科技期刊数据库和万方数据库,收集前列地尔注射液不同给药方式致静脉炎的随机对照试验(RCT),筛选文献、提取数据并按照Cochrane系统评价员手册5.1.0评价质量后,采用Rev Man 5.2统计软件进行Meta分析。结果: 共纳入20项RCT,合计2 562例患者。Meta分析结果显示,静脉注射前列地尔注射液致静脉炎发生率显著高于小壶静脉滴注[OR=4.11,95%CI(1.59, 10.67),P=0.004]和静脉泵入[OR=3.50, 95%CI(1.50, 8.16),P=0.004];普通输液器致静脉炎发生率显著高于精细过滤输液器[OR=0.03,95%CI(0.01,0.08),P<0.001],差异均有统计学意义。结论:低浓度的前列地尔注射液,或使用精细过滤输液器致静脉炎发生率较低,静脉注射给药致静脉炎发生率较高。 |
ABSTRACT: | OBJECTIVE: To systematically review the difference of phlebitis induced by Alprostadil injection with different administration routes, and to provide evidence-based reference for clinical rational use. METHODS: Retrieved from PubMed, EMBase, Cochrane Library, CBM, CJFD, VIP and Wanfang database, RCTs about phlebitis induced by Alprostadil injection with different administration routes were collected. Meta-analysis was conducted by Rev Man 5.2 statistical software after literature screening, data extraction and quality evaluation according to Cochrane System Evaluator’s Manual 5.1.0. RESULTS: A total of 20 RCTs were included, involving 2 562 patients. The results of Meta-analysis showed that the incidence of phlebitis induced by intravenous injection was significantly higher than that induced by intravenous dripping [OR=4.11,95%CI(1.59,10.67),P=0.004] and intravenous pump [OR=3.50,95%CI(1.50,8.16),P=0.004]. The incidence of phlebitis induced by general apparatus infusion was significantly higher than that induced by fine filtering infusion [OR=0.03,95%CI(0.01,0.08),P<0.001], with statistical significance. CONCLUSIONS: The incidence of phlebitis induced by low-concentration of Alprostadil injection or fine filtering infusion is lower, and that of intravenous injection is higher. |
期刊: | 2017年第28卷第21期 |
作者: | 田方圆,邹敏,吴斌,徐珽,蒋学 |
AUTHORS: | TIAN Fangyuan,ZOU Min,WU Bin,XU Ting,JIANG Xuehua |
关键字: | 前列地尔注射液;静脉炎;剂量;输液器;给药途径;系统评价 |
KEYWORDS: | Alprostadil injection; Phlebitis; Dose; Apparatus infusion; Route of administration; Systematic review |
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