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双环醇联合更昔洛韦治疗婴儿巨细胞病毒性肝炎的临床观察
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| 篇名： | 双环醇联合更昔洛韦治疗婴儿巨细胞病毒性肝炎的临床观察 |
| TITLE： | |
| 摘要： | 目的：探究双环醇联合更昔洛韦治疗婴儿巨细胞病毒性肝炎的临床疗效及安全性。方法：选取2012年5月－2015年8月我院儿科收治的巨细胞病毒性肝炎患儿120例，按随机数字表法分为观察组和对照组，各60例。两组患儿均给予常规治疗，包括保肝、补充维生素C和维生素K等，并给予复方甘草酸苷注射液20 mL，ivgtt，qd。对照组患儿在上述治疗的基础上给予更昔洛韦葡萄糖注射液（诱导期5 mg/kg，q12 h，每次滴注时间＞1 h，持续7 d；维持期5 mg/kg，q24 h，持续7 d）；观察组患儿在对照组的基础上口服双环醇片0.5 mg/kg，bid。观察两组患儿临床疗效及治疗前后肝酶、黄疸水平，并比较CMV转阴率及不良反应发生情况。 结果：观察组患儿临床总有效率为93.3％，显著高于对照组的80.0％，差异有统计学意义（P＜0.05）。治疗前，两组患儿肝酶和黄疸水平比较，差异均无统计学意义（P＞0.05）；治疗后，两组患儿肝酶和黄疸水平均显著降低，且观察组水平显著低于对照组，差异均有统计学意义（P＜0.05）。观察组患儿CMV总转阴率为85.0％，显著高于对照组的73.3％，差异有统计学意义（P＜0.05）。两组患儿不良反应发生率比较，差异无统计学意义（P＞0.05）。结论：双环醇联合更昔洛韦治疗婴儿巨细胞病毒性肝炎疗效显著，能有效降低患儿血清肝酶水平、消除黄疸、保护肝功能、促进病毒转阴，且安全性较高。 |
| ABSTRACT： | OBJECTIVE： To explore the effectiveness and safety of bicyclol combined with ganciclovir in the treatment of infantile cytomegaloirus hepatitis. METHODS： One hundred and twenty children with cytomegaloirus hepatitis in department of pediatrics of our hospital during May 2012-Aug. 2015 were selected and divided into observation group and control group according to random number table， with 60 cases in each group. Both groups received conventional treatment such as protecting liver， vitamin C， vitamin K and Compound glycyrrhizin injection 20 mL， ivgtt， qd. Control group additionally received Ganciclovir injection （induction period： 5 mg/kg，q12 h， dripping time ＞1 h， for 7 d； maintenance period： 5 mg/kg，q24 h，for 7 d）； observation group was additionally given Bicyclol tablet 0.5 mg/kg，bid， on the basis of control group. Clinical efficacies of 2 groups were observed as well as liver enzyme level， jaundice level before and after treatment. The rate of negative CMV and the occurrence of ADR were compared. RESULTS： Clinical total response rate of observation group was 93.3％， which was significantly higher than 80.0％ of control group， with statistical significance （P＜0.05）. There was no statistical significance in liver enzyme level and jaundice level between 2 groups before treatment （P＞0.05）. After treatment， liver enzyme level and jaundice level of 2 groups were decreased significantly， and observation group was significantly lower than control group， with statistical significance （P＜0.05）. The rate of total negative CMV in observation group was 85.0％， which was significantly higher than 73.3％ of control group， with statistical significance （P＜0.05）. There was no statistical significance in the incidence of ADR between 2 groups （P＞0.05）. CONCLUSIONS： Bicyclol combined with ganciclovir shows significant therapeutic efficacy for infantile cytomegaloirus hepatitis， and can effectively reduce the levels of liver enzymes， eliminate jaundice， protect liver function， promote virus clearance with good safety. |
| 期刊： | 2017年第28卷第23期 |
| 作者： | 郑华月，郑春阳 |
| AUTHORS： | ZHENG Huayue，ZHENG Chunyang |
| 关键字： | 双环醇；更昔洛韦；巨细胞病毒性肝炎；婴儿；黄疸；肝酶 |
| KEYWORDS： | Bicyclol； Ganciclovir； Cytomegaloirus hepatitis； Infantile； Jaundice； Liver enzyme |
| 阅读数： | 346 次 |
| 本月下载数： | 14 次 |
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