布地奈德或丙酸倍氯米松联合特布他林治疗小儿轻中度哮喘急性发作的疗效和安全性比较-中国药房

布地奈德或丙酸倍氯米松联合特布他林治疗小儿轻中度哮喘急性发作的疗效和安全性比较

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篇名：	布地奈德或丙酸倍氯米松联合特布他林治疗小儿轻中度哮喘急性发作的疗效和安全性比较
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摘要：	目的：比较布地奈德或丙酸倍氯米松联合特布他林治疗小儿轻中度哮喘急性发作的疗效和安全性。方法：110例轻中度哮喘急性发作患儿随机分为A组（55例）和B组（55例）。在常规治疗的基础上，A组患儿给予硫酸特布他林雾化液1 mL，雾化吸入，每日2次+吸入用布地奈德混悬液2 mL，雾化吸入，每日2次；B组患儿给予硫酸特布他林雾化液（用法用量同A组）+吸入用丙酸倍氯米松混悬液2 mL，雾化吸入，每日2次。两组疗程均为7 d。观察两组患儿的临床疗效、症状体征消失时间、住院时间、哮喘缓解率，治疗前后症状体征评分、呼气峰流速（PEF）及不良反应发生情况。结果：两组患儿总有效率、症状体征消失时间、住院时间、哮喘缓解率、不良反应发生率比较，差异均无统计学意义（P＞0.05）。治疗后，两组患儿症状体征评分均显著低于同组治疗前，PEF均显著高于同组治疗前，差异均有统计学意义（P＜0.05）；但两组间比较差异均无统计学意义（P＞0.05）。结论：在常规治疗的基础上，布地奈德或丙酸倍氯米松联合特布他林均可用于治疗小儿轻中度哮喘急性发作，且两者的疗效和安全性均相当。
ABSTRACT：	OBJECTIVE： To compare therapeutic efficacy and safety of budesonide or beclometasone combined with terbutanline in the treatment of acute attack of mild and moderate asthma in children. METHODS： A total of 110 children with mild and moderate asthma were randomly divided into group A （55 cases） and group B （55 cases）. Based on routine treatment， group A was given Terbutaline sulphate solution for nebulization 1 mL， nebulization inhalation， twice a day+Budesonide suspension for inhalation 2 mL， nebulization inhalation， twice a day. Group B was given Terbutaline sulphate solution for nebulization （same usage and dosage as group A）+Beclomethasone dipropionate suspension for inhalation 2 mL， nebulization inhalation， twice a day. Treatment courses of 2 groups lasted for 7 d. Clinical efficacies， symptoms and signs disappearance time， hospitalization time， asthma relief rate as well as symptoms and signs scores， peak value expiration velocity of flow （PEF）， the occurrence of ADR were observed in 2 groups. RESULTS： There was no statistical significance in total response rate， symptoms and signs disappearance time， hospitalization time， asthma relief rate or the incidence of ADR between 2 groups （P＞0.05）. After treatment， symptoms and signs scores of 2 groups were significantly lower than before， while the PEF were significantly higher than before， with statistical significance （P＜0.05），but there was no statistical significance between 2 groups （P＞0.05）. CONCLUSIONS： Based on routine treatment， budesonide or beclometasone combined with terbutaline sulphate can be used for acute attack of mild and moderate asthma in children. They are similar to each other in therapeutic efficacy and safety.
期刊：	2017年第28卷第24期
作者：	蔡亲武，杨子江，王昌乐
AUTHORS：	CAI Qinwu，YANG Zijiang，WANG Changle
关键字：	布地奈德；丙酸倍氯米松；特布他林；小儿；哮喘急性发作；疗效；安全性
KEYWORDS：	Budesonide； Beclometasone； Terbutaline； Children； Acute attack of asthma； Therapeutic efficacy； Safety
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