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迈之灵联合常规药物治疗精索静脉曲张的临床研究
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| 篇名： | 迈之灵联合常规药物治疗精索静脉曲张的临床研究 |
| TITLE： | |
| 摘要： | 目的：探讨迈之灵联合常规药物治疗精索静脉曲张（VC）的临床效果。方法：选择2015年2月－2016年1月我院收治的86例VC患者为研究对象，按照就诊单双号分为对照组和观察组，各43例。对照组患者给予常规药物（枸橼酸氯米芬、左卡尼汀）治疗；观察组患者在对照组基础上加用迈之灵片300 mg，po，bid。两组患者疗程均为3个月。比较两组患者的临床疗效，治疗前后的睾丸动脉血流动力学参数、精浆实验室检查指标、精液质量，以及不良反应发生情况。结果：观察组患者的总有效率为90.70％，明显高于对照组的72.09％，差异有统计学意义（P＜0.05）。治疗前，两组患者的上述指标比较，差异均无统计学意义（P＞0.05）。治疗后，两组患者睾丸动脉向心支的收缩期峰值流速、阻力指数和搏动指数均较治疗前明显降低，α-葡糖苷酶、精浆酸性磷酸酶、精浆果糖含量和前向运动精子活动率、精子总活动率均较治疗前明显升高，精子密度均较治疗前明显增大，且观察组各指标均优于对照组，差异均有统计学意义（P＜0.05）；但治疗前后两组患者睾丸动脉向心支的舒张末期流速比较，差异均无统计学意义（P＞0.05）。两组患者均未见明显不良反应发生。结论：迈之灵联合常规药物有助于改善VC患者睾丸动脉血流状态，调节精浆相关分子含量，提高精液质量，从而提高临床疗效，且安全性较高。 |
| ABSTRACT： | OBJECTIVE： To investigate clinical effects of aescuven forte combined with routine drugs in the treatment of varicocele （VC）. METHODS： A total of 86 patients with VC selected from our hospital during Feb. 2015-Jan. 2016 were divided into control group and observation group according to odd and even number， with 43 cases in each group. Control group was given routine drug therapy. Observation group was additionally given Aescuven forte tablet 300 mg， po， bid， on the basis of control group. Treatment course of 2 groups lasted for 3 months. Clinical efficacies as well as testicular artery blood flow parameters， seminal plasma lab indexes and semen quality were compared between 2 groups. The occurrence of ADR was also compared between 2 groups. RESULTS： Total response rate of observation group was 90.70％， which was significantly higher than 72.09％ of control group， with statistical significance （P＜0.05）. Before treatment， there was no statistical significance in above indexes between 2 groups （P＞0.05）. Compared to before treatment， testicular artery peak systolic velocity， resistance index and pulsatility index of 2 groups were decreased significantly after treatment， while plasma α-glucosidase， acid phosphatase， Fructose， sperm activate rate of forward movement， total sperm activate rate and sperm density were increased significantly； each index of observation group was better than that of control group， with statistical significance （P＜0.05）； there was no statistical significance in end diastolic velocity between 2 groups before and after treatment （P＞0.05）. No obvious ADR was found in 2 groups. CONCLUSIONS： Aescuven forte combined with routine drug therapy help to improve testicular artery blood flow status of VC patients， regulate the content of seminal plasma related molecules and improve semen quality so as to improve clinical efficacy with good safety. |
| 期刊： | 2017年第28卷第26期 |
| 作者： | 叶纪伟，沈远径 |
| AUTHORS： | YE Jiwei，SHEN Yuanjing |
| 关键字： | 精索静脉曲张；迈之灵；睾丸动脉血流；精浆实验室检查指标；精液质量 |
| KEYWORDS： | Varicocele； Aescuven forte； Testicular artery blood flow； Seminal plasma lab index； Semen quality |
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