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非瓣膜性房颤患者华法林用药依从性及其影响因素的调查分析
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| 篇名： | 非瓣膜性房颤患者华法林用药依从性及其影响因素的调查分析 |
| TITLE： | |
| 摘要： | 目的：为改善非瓣膜性房颤患者用药依从性，更好地保证治疗安全性和有效性提供参考。方法：选取部分在我院住院接受华法林抗凝治疗的非瓣膜性房颤患者进行问卷调查，分别采用8条目Morisky用药依从性量表（MMAS-8）和华法林用药知识量表（WRKS）评估患者华法林用药依从性及抗凝治疗相关知识知晓情况，并应用χ2检验、t检验及Logistic多元回归分析方法探讨影响患者华法林用药依从性的相关因素。结果：共发放问卷129份，回收有效问卷112份，有效回收率为86.82％。受访患者MMAS-8平均得分为（6.54±1.61）分，用药依从性好者占42.86％。受访患者WRKS平均得分为（7.95±1.65）分，用药依从性好者平均得分为（9.31±0.83）分，用药依从性差者平均得分为（6.92±1.34）分。单因素分析发现，用药依从性好者与用药依从性差者在性别、年龄、职业、文化程度、合并症种数、WRKS得分等方面比较，差异均有统计学意义（P＜0.05）。Logistic多元回归分析结果显示，WRKS得分、性别、文化程度、合并症种数与受访患者用药依从性均显著相关（P＜0.05）。结论：非瓣膜性房颤患者华法林用药依从性较差，与多种影响因素相关，其中华法林抗凝治疗相关知识知晓情况是一个重要因素。 |
| ABSTRACT： | OBJECTIVE： To improve medication compliance of patients with nonvalvular atrial fibrillation （NVAF） to warfarin and its influential factors， and to provide reference for guaranteeing the safety and effectiveness of therapy. METHODS： A questionnaire survey was conducted among NVAF patients receiving warfarin anticoagulation in our hospital， MMAS-8 and WRKS were adopted to evaluate medication compliance of patients to warfarin and the understanding of patients to the knowledge of anticoagulation treatment. Related influential factors for medication compliance of patients to warfarin were investigated by χ2 test， t test and Logistic multiple regression analysis. RESULTS： Totally 129 questionnaires were sent out， and 112 were effectively received with effective recovery of 86.82％. The mean score of MMAS was （6.54±1.61）， and 42.86％ patients had good medication compliance. The mean score of WRKS was （7.95±1.65）； that of patients with good medication compliance was （9.31±0.83）， and that of patients with poor medication compliance was （6.92±1.34）. Single factor analysis showed that there was statistical significance in gender， age， occupation， educational level， the number of compliance， WRKS score between patients with good medication compliance and those with poor medication compliance （P＜0.05）. Multivariate Logistic regression analysis showed that WRKS score， gender， educational level and the number of compliance were significantly correlated with medication compliance （P＜0.05）. CONCLUSIONS： Poor medication compliance of NVAF patients to warfarin is related to multiple influential factors. The knowledge of warfarin anticoagulation is an important factor. |
| 期刊： | 2017年第28卷第27期 |
| 作者： | 陈文文，党和勤，耿涛，张秀珍，李元民 |
| AUTHORS： | CHEN Wenwen，DANG Heqin，GENG Tao，ZHANG Xiuzhen，LI Yuanmin |
| 关键字： | 非瓣膜性房颤；华法林；用药依从性；影响因素 |
| KEYWORDS： | Nonvalvular atrial fibrillation； Warfarin； Medication compliance； Influential factor |
| 阅读数： | 314 次 |
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