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口炎清颗粒对头颈部恶性肿瘤患者放疗后放射性口腔黏膜炎的防治作用
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| 篇名： | 口炎清颗粒对头颈部恶性肿瘤患者放疗后放射性口腔黏膜炎的防治作用 |
| TITLE： | |
| 摘要： | 目的： 探讨口炎清颗粒对头颈部恶性肿瘤患者放疗后放射性口腔黏膜炎的防治作用。方法：122例行放疗的头颈部恶性肿瘤患者随机分为口炎清组（61例）和氯己定组（61例）。在放疗的基础上，口炎清组患者于放疗前2～3 d给予口炎清颗粒20 g，溶于50 mL温开水含服，每日2次；氯己定组患者于放疗前2～3 d给予复方氯己定含漱液10～20 mL，含漱，每日2次。两组疗程均为7周。观察两组患者口腔黏膜炎反应发生情况，视觉模拟（VAS）评分及不良反应发生情况。结果：放疗第3周后口炎清组患者2～3级及放疗第4～7周后2～4级口腔黏膜炎发生率均显著低于氯己定组同期，差异均有统计学意义（P＜0.01）。放疗第2～7周后，口炎清组患者VAS评分均显著低于氯己定组，差异均有统计学意义（P＜0.01）。两组患者不良反应发生率比较，差异无统计学意义（P＞0.05）。结论：口炎清颗粒可降低头颈部恶性肿瘤患者放疗后放射性口腔黏膜炎的反应严重程度，减轻患者疼痛，改善患者生存质量，且安全性与氯己定相当。 |
| ABSTRACT： | OBJECTIVE： To investigate the effects of Kouyanqing granules on prevention and treatment of radiation-induced oral mucositis patients with head and neck cancer after radiotherapy. METHODS：A total of 122 head and neck cancer patients receiving radiotherapy were randomly divided into kouyanqing group （61 cases） and chlorhexidine group （61 cases）. Based on radiotherapy， kouyanqing group was given Kouyanqing granules 20 g dissolved in 50 mL lukewarm boiled water， twice a day， 2-3 d before radiotherapy. Chlorhexidine group was given Compound chlorhexidine gargle 10-20 mL， twice a day， 2-3 d before radiotherapy. Treatment courses of 2 groups lasted for 7 weeks. The occurrence of oral mucositis， VAS scores and ADR were observed in 2 groups. RESULTS： 3rd week radiotherapy later，the incidence of oral mucositis at level 2-3 and 4th-7th week radiotherapy later， the incidence of oral mucositis at level 2-4 in kouyanqing group was significantly lower than chlorhexidine group， with statistical significance （P＜0.01）. 2nd-7th week radiotherapy later， VAS score of kouyanqing group was significantly lower than that of chlorhexidine group， with statistical significance （P＜0.01）. There was no statistical significance in the incidence of ADR between 2 groups （P＞0.05）. CONCLUSIONS： Kouyanqing granules can relieve radiation-induced oral mucositis of head and neck cancer and the degree of pain，and improve the quality of life. Its safety is similar to that of chlorhexidine. |
| 期刊： | 2017年第28卷第27期 |
| 作者： | 严齐会， 林海升，卓文杰，范优敏，戴杰 |
| AUTHORS： | YAN Qihui，LIN Haisheng，ZHUO Wenjie，FAN Youmin，DAI Jie |
| 关键字： | 口炎清颗粒；头颈部肿瘤；放疗；口腔黏膜炎；疼痛程度；疼痛评分 |
| KEYWORDS： | Kouyanqing granules； Head and neck cancer； Radiotherapy； Oral mucositis； Degree of pain； Pain score |
| 阅读数： | 512 次 |
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