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桦木酸纳米粒的制备与表征
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| 篇名： | 桦木酸纳米粒的制备与表征 |
| TITLE： | |
| 摘要： | 目的：制备桦木酸纳米粒，并对其进行表征。方法：以乙醇为溶剂、水为反溶剂，采用反溶剂重结晶法制备桦木酸纳米粒。以粒径为指标，采用单因素试验与正交试验优化桦木酸纳米粒处方工艺中桦木酸溶液质量浓度、反溶剂-溶剂体积比、反溶剂滴加速度、反应温度和搅拌速度，并进行验证试验。采用扫描电子显微镜、激光粒度仪、傅里叶红外光谱仪和质谱分析仪对所制得的桦木酸纳米粒进行表征。结果：最优处方工艺为桦木酸溶液质量浓度为3 mg/mL、反溶剂-溶剂体积比为1 ∶ 1、反溶剂滴加速度为8 mL/min、反应温度为20 ℃、搅拌速度为900 r/min；所制桦木酸纳米混悬液粒径为（156.0±8.6） nm（n＝3），冻干后粒径为（235.0±12.2） nm（n＝3），外观近球形、大小均匀、形态较规整；与桦木酸原料药比较，所制桦木酸纳米粒的化学结构没有发生改变，分子量和质荷比无明显变化。结论：成功制得桦木酸纳米粒。 |
| ABSTRACT： | OBJECTIVE： To prepare the betulinic acid nanoparticles， and characterize them. METHODS： Using ethanol as solvent and water as anti-solvent， anti-solvent recrystallization method was used to prepare betulinic acid nanoparticles. Using particle size as indicator， single factor test and orthogonal test were adopted to optimize the mass concentration of betulinic acid solution， anti-solvent-solvent volume ratio， anti-solvent drip rate， reaction temperature and stirring speed in formulation technology of betulinic acid nanoparticles， and verification test was conducted. The betulinic acid nanoparticles were characterized by scanning electron microscopy， laser particle size analyzer， Fourier infrared spectrometer and mass spectrum analyzer. RESULTS： The optimal technology was as follow as betulinic acid solution mass concentration of 3 mg/mL， anti-solvent-solvent volume ratio of 1 ∶ 1， anti-solvent drip rate of 8 mL/min， reaction temperature of 20 ℃ and stirring speed of 900 r/min. The average size of prepared betulinic acid nanosuspension was （156.0±8.6） nm （n＝3） and the particle size was （235.0±12.2） nm （n＝3） after freeze-drying， with nearly spherical appearance， uniform size and regular form. Compared with raw material of betulinic acid， the chemical structure of prepared betulinic acid nanoparticles did not change， and there were no significant changes in molecular weight and mass ratio. CONCLUSIONS： Betulinic acid nanoparticles are successfully prepared. |
| 期刊： | 2017年第28卷第31期 |
| 作者： | 吴铭芳，许文佳，祖元刚，赵修华 |
| AUTHORS： | WU Mingfang，XU Wenjia，ZU Yuangang，ZHAO Xiuhua |
| 关键字： | 桦木酸；纳米粒；反溶剂重结晶法；单因素试验；正交试验；表征 |
| KEYWORDS： | Betulinic acid； Nanoparticles； Anti-solvent recrystallization method； Single factor test； Orthogonal test； Characterization |
| 阅读数： | 293 次 |
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