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维生素D联合阿奇霉素对2型糖尿病患者肺炎的影响
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| 篇名： | 维生素D联合阿奇霉素对2型糖尿病患者肺炎的影响 |
| TITLE： | |
| 摘要： | 目的：探讨维生素D联合阿奇霉素治疗2型糖尿病患者肺炎的临床疗效和安全性，及其对血清炎症指标的影响。方法：选取我院2014年5月－2015年9月收治的2型糖尿病伴肺炎患者68例，按照随机数字表法将患者分为对照组和试验组，各34例。两组患者均给予胰岛素强化降糖。对照组患者给予注射用阿奇霉素10 mg/kg+0.9％氯化钠注射液500 mL，ivgtt，qd，连续应用5 d后改用阿奇霉素干混悬剂10 mg/kg，po，qd，连用3 d后停药4 d为1个疗程，给药2个疗程；试验组患者在对照组基础上给予维生素D滴剂800单位，po，qd，连续给药4周。观察两组患者的临床疗效、治疗前后的血清炎症指标[白细胞介素6（IL-6）、C反应蛋白（CRP）和免疫球蛋白G（IgG）]水平，并记录不良反应发生情况。结果：试验组患者临床总有效率（91.18％）显著高于对照组（70.59％），差异有统计学意义（P＜0.05）。治疗前，两组患者IL-6、CRP和IgG等血清炎症指标比较，差异均无统计学意义（P＞0.05）。治疗后，两组患者IL-6和CRP均显著降低，且试验组显著低于对照组；两组患者IgG显著升高，且试验组显著高于对照组，差异均有统计学意义（P＜0.05）。两组患者不良反应发生率比较，差异无统计学意义（P＞0.05）。结论：维生素D联合阿奇霉素治疗2型糖尿病患者肺炎的临床效果显著，有助于改善其血清IL-6、CRP和IgG等炎症因子水平，且安全性较高。 |
| ABSTRACT： | OBJECTIVE： To investigate clinical efficacy and safety of vitamin D combined with azithromycin in the treatment of pneumonia in patients with type 2 diabetes and its effects on serum inflammation indexes. METHODS： A total of 68 patients with type 2 diabetes complicated with pneumonia selected from our hospital during May 2014-Sept. 2015 were divided into control group and trial group according to random number table， with 34 cases in each group. Both groups received insulin intensive hypoglycemic therapy. Control group was given Azithromycin for injection 10 mg/kg+0.9％ Sodium chloride injection 100 mL， ivgtt， qd， for consecutive 5 d， and then used Azithromycin dry suspension instead 10 mg/kg， po， qd， consecutive 3 d treatment and 4 d interval as a treatment course， for 2 cycles. Trial group was additionally given Vitamin D drops 800 U， po， qd， for consecutive 4 weeks， on the basis of control group. The clinical efficacies of 2 groups were observed， and serum inflammation indexes [interleukin-6 （IL-6）， C-reactive protein （CRP）， immunoglobulin G protein （IgG）] levels were also observed before and after treatment. The occurrence of ADR was recorded. RESULTS： Total response rate of trial group （91.18％） was significantly higher than that of control group （70.59％）， with statistical significance （P＜0.05）. Before treatment， there was no statistical significance in serum inflammation indexes as IL-6， CRP， IgG between 2 group （P＞0.05）. After treatment， IL-6 and CRP of 2 groups were decreased significantly， and the trial group was significantly lower than the control group； IgG of 2 groups were increased significantly， and the trial group was significantly higher than the control group， with statistical significance （P＜0.05）. There was no statistical significance in the incidence of ADR between 2 groups （P＞0.05）. CONCLUSIONS： Vitamin D combine with azithromycin in the treatment of pneumonia in patients with type 2 diabetes has a good clinical curative effect， helps to improve the levels of IL-6， CRP and IgG with good safety. |
| 期刊： | 2017年第28卷第32期 |
| 作者： | 张永敬，么焕新，柴颖，王淑珍 |
| AUTHORS： | ZHANG Yongjing，YAO Huanxin，CHAI Ying，WANG Shuzhen |
| 关键字： | 维生素D；阿奇霉素；2型糖尿病；肺炎；白细胞介素6；C反应蛋白；免疫球蛋白G |
| KEYWORDS： | Vitamin D； Azithromycin； Type 2 diabetes； Pneumonia； Interleukin-6； C reactive protein； Immunoglobulin G protein |
| 阅读数： | 389 次 |
| 本月下载数： | 2 次 |
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