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某院门诊奥美拉唑超说明书用药情况调查分析
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| 篇名： | 某院门诊奥美拉唑超说明书用药情况调查分析 |
| TITLE： | |
| 摘要： | 目的：调查门诊奥美拉唑超说明书用药情况，为临床合理用药提供参考。方法： 采用回顾性调查的方法，并用随机数字表法抽取某院门诊2014年6月－2017年5月使用奥美拉唑的处方1 838张，根据最新版药品说明书，判断是否超说明书用药；通过查阅国内外指南、文献和Micromedex数据库等对超说明书用药进行分析。结果：1 838张处方中，超说明书用药处方有1 750张（95.21％），涉及3种类型、13项超说明书用药内容。超说明书用药类型主要为超适应证用药，共1 747张（96.47％）。消化内科和非消化内科超说明书用药发生率、不同级别医师超说明书用药发生率比较，差异均无统计学意义（P＞0.05）。13项超说明书用药内容中，7项有国内外指南、专家共识/建议或文献报道等不同级别的循证医学证据支持，但其中仅有1项被Micromedex的Thomson分级系统收录，其余6项均无任何循证医学证据。结论：该院门诊奥美拉唑超说明书用药现象普遍，部分超说明书用药有证据支持，但各证据质量存在差异。临床应规范说明书应用以避免法律风险，确保患者安全用药。 |
| ABSTRACT： | OBJECTIVE： To investigate the omeprazole off-label use and provide reference for rational drug use in clinic. METHODS： In retrospective survey， 1 838 omeprazole prescriptions were selected from outpatient department during Jun. 2014 to May 2017 by random number table. According to the latest drug instruction， whether the off-label use or not was determined. Off-label use was determined by reviewing domestic and foreign guidelines， literatures and Micromedex database. RESULTS： Among 1 838 prescriptions， there were 1 750 prescriptions of off-label drug use （95.21％）， involving 13 items and 3 types of off-label drug use. Main type of off-label drug use was over-indication medication， involving 1 747 prescriptions （96.47％）. There was no statistical significance in the incidence of off-label drug use between digestive department and non-digestive department or among physicians at different levels （P＞0.05）. Among 13 items of off-label drug use， 7 items were supported by evidence-based medicine evidence of domestic and foreign guideline， expert consensus/suggestion or literature reports， etc.； among which 1 item of off-label drug use were included in Micromedex grading system and other 6 items had no evidence-based medicine evidence. CONCLUSIONS： The phenomenon of omeprazole off-label use is widespread in outpatient department of the hospital， and some off-label drug use are supported by evidences. There are differences in the quality of those evidences. It is suggested to standardize the off-label drug use to avoid legal risks and guarantee the safety of drug use for patients. |
| 期刊： | 2017年第28卷第35期 |
| 作者： | 蒋炜，吴晓玲，周敏华，谢奕丹，王艳，黄光鸿 |
| AUTHORS： | JIANG Wei，WU Xiaoling，ZHOU Minhua，XIE Yidan，WANG Yan，HUANG Guanghong |
| 关键字： | 门诊；奥美拉唑；超说明书用药；分析 |
| KEYWORDS： | Outpatient department； Omeprazole； Off-label drug use；Analysis |
| 阅读数： | 466 次 |
| 本月下载数： | 14 次 |
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