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薤白对高脂血症模型大鼠血脂水平的影响及机制研究
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| 篇名： | 薤白对高脂血症模型大鼠血脂水平的影响及机制研究 |
| TITLE： | |
| 摘要： | 目的：考察薤白对高脂血症模型大鼠血脂水平的影响及机制，为薤白降血脂的临床应用提供参考。方法：取10只正常大鼠作为正常对照组，饲以普通饲料；另取50只大鼠饲以高脂饲料，复制高脂血症大鼠模型。取成模大鼠40只随机分为模型组（饲以高脂饲料）和薤白低、中、高剂量组（0.83、1.67、2.50 g/kg，分别饲以含10％薤白的高脂饲料8.3、16.7、25.0 g/kg，不足采食量者用高脂饲料补足）。饲养45 d后，检测大鼠血清中总胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白（LDL-C）、高密度脂蛋白（HDL-C）含量，计算大鼠肝、脾、肾、心脏指数，并检测大鼠肝组织中低密度脂蛋白受体（LDLR）、肝X受体α（LXRα）mRNA表达水平。结果：与正常对照组比较，模型组大鼠血清中TC、LDL-C含量和肝指数显著升高，血清中HDL-C含量和肝组织中LDLR、LXRα mRNA表达水平显著降低，差异均有统计学意义（P＜0.01）。与模型组比较，薤白各剂量组大鼠血清中TC、LDL-C含量显著降低，HDL-C含量显著升高；且薤白中、高剂量组大鼠肝组织中LDLR、LXRα mRNA表达水平显著升高，肝、脾指数显著降低，差异均有统计学意义（P＜0.05或P＜0.01）。结论：薤白具有较好的降血脂作用，其机制可能与上调肝组织中LDLR、LXRα mRNA的表达有关。 |
| ABSTRACT： | OBJECTIVE： To investigate the effect and mechanism of Allii macrostemonis bulbus on blood lipid levels in hyperlipidemia model rats， and to provide reference for clinical use of Allii macrostemonis bulbus to reduce blood lipid. METHODS： A total of 10 normal rats were included in normal control group and given common diet. Other 50 rats were given hyperlipid diet to induce hyperlipidemia rat model. 40 model rats were randomly divided into model group （hyperlipid diet）， Allii macrostemonis bulbus low-dose， medium-dose and high-dose groups （0.83， 1.67， 2.50 g/kg， fed by hyperlipid diet which containing 10％Allii macrostemonis bulbus 8.3， 16.7， 25.0 g/kg， fill with hyperlipid feed in patients with insufficient food intake）. After fed for 45 d， the contents of TC， TG， LDL-C and HDL-C in serum of rats were detected. Liver， spleen， renal and cardiac indexes of rats were calculated. mRNA expression of low density lipoprotein receptor （LDLR） and liver X-receptor α （LXRα）were detected in liver tissue of rats. RESULTS： Compared with normal control group， the contents of TC and LDL-C in serum and liver index of rats were increased significantly in model group， while the content of HDL-C in serum and mRNA expressions of LDLR and LXRα in liver tissue were decreased significantly， with statistical significance （P＜0.01）. Compared with model group， the contents of TC and LDL-C in serum were decreased significantly in Allii macrostemonis bulbus groups， while the content of HDL-C was increased significantly. mRNA expressions of LDLR and LXRα in liver tissue were increased significantly in Allii macrostemonis bulbus medium-dose and high-dose groups， while liver and spleen indexes were decreased significantly， with statistical significance （P＜0.05 or P＜0.01）. CONCLUSIONS： Allii macrostemonis bulbus shows good blood-lipid lowering effect， the mechanism of which may be associated with up-regulating mRNA expressions of LDLR and LXRα in liver tissue. |
| 期刊： | 2018年第29卷第7期 |
| 作者： | 鞠楷，万语嫣，张开莲 |
| AUTHORS： | JU Kai，WAN Yuyan，ZHANG Kailian |
| 关键字： | 薤白；高脂血症；降血脂；低密度脂蛋白受体；肝X受体α；大鼠 |
| KEYWORDS： | Allii macrostemonis bulbus； Hyperlipidemia； Blood-lipid lowering； Low density lipoprotein receptor； Liver X-receptor α； Rat |
| 阅读数： | 395 次 |
| 本月下载数： | 28 次 |
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