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微创旋切术后给予乳癖散结胶囊治疗乳腺增生的临床观察
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| 篇名： | 微创旋切术后给予乳癖散结胶囊治疗乳腺增生的临床观察 |
| TITLE： | |
| 摘要： | 目的：观察微创旋切术后给予乳癖散结胶囊治疗乳腺增生的疗效和安全性。方法：回顾性收集2015年5月－2017年5月苏州大学附属第一医院普外科收治的180例乳腺增生或乳腺增生合并乳腺纤维瘤患者资料，根据用药方法的不同分为对照组（n＝90）和观察组（n＝90）。两组患者均采用微创旋切术治疗。术后，对照组患者给予枸橼酸他莫昔芬片10 mg，口服，每日2次；观察组患者给予乳癖散结胶囊2.12 g，口服，每日3次。两组患者月经期间停止用药，且疗程均为8周。观察两组患者的临床疗效，治疗前后血管内皮生长因子（VEGF）、成纤维细胞生长因子（FGF）水平和微血管密度（MVD）及不良反应发生情况。结果：观察组患者总有效率（95.56％）显著高于对照组（86.67％），差异有统计学意义（P＜0.05）。治疗前，两组患者VEGF、FGF水平及MVD比较，差异均无统计学意义（P＞0.05）；治疗后，两组患者VEGF、FGF水平及MVD均显著低于同组治疗前，且观察组显著低于对照组，差异均有统计学意义（P＜0.05）。两组患者治疗期间均未见明显不良反应发生。结论：微创旋切术后给予乳癖散结胶囊治疗乳腺增生的疗效显著，可降低VEGF、FGF水平及MVD，且安全性较高。 |
| ABSTRACT： | OBJECTIVE： To observe therapeutic efficacy and safety of Rupi sanjie capsules in the treatment of mammary gland hyperplasia after minimally invasive rotation and surgical. METHODS： A total of 180 patients with mammary gland hyperplasia or mammary gland hyperplasia combined with mammary fibroma were selected retrospectively from general surgery department of the First Affiliated Hospital of Soochow University during May 2015 to May 2017. They were divided into control group （n＝90） and observation group （n＝90） according to medication methods. Both groups received minimally invasive rotation and surgical treatment. After operation， control group was given Tamoxifen citrate tablets 10 mg orally， twice a day. Observation group was given Rupi sanjie capsules 2.12 g orally， 3 times a day. Two groups stopped taking medication during menstruation， and both groups were treated for 8 weeks. Clinical efficacies of 2 groups were observed， and the levels of VEGF， FGF and MVD， the occurrence of ADR were observed before and after treatment. RESULTS： The total response rate of observation group （95.56％） was significantly higher than that of control group （86.67％）， with statistical significance （P＜0.05）. Before treatment， there was no statistical significance in the levels of VEGF， FGF and MVD between 2 groups （P＞0.05）. After treatment， the levels of VEGF， FGF and MVD in 2 groups were significantly lower than before treatment， and the observation group was significantly lower than the control group， with statistical significance （P＜0.05）. No obvious ADR was found in 2 groups during treatment. CONCLUSIONS： After minimally invasive rotation and surgical， Rupi sanjie capsules shows significant therapeutic efficacy for mammary gland hyperplasia， can reduce the levels of VEGF， FGF and MVD with good safety. |
| 期刊： | 2018年第29卷第12期 |
| 作者： | 吕庆福，陈琳，过兆基，曹苇，姜敏 |
| AUTHORS： | LYU Qingfu，CHEN Lin，GUO Zhaoji，CAO Wei，JIANG Min |
| 关键字： | 乳癖散结胶囊；枸橼酸他莫昔芬片；微创旋切术；乳腺增生；疗效；安全性 |
| KEYWORDS： | Rupi sanjie capsules； Tamoxifen citrate tablets； Minimally invasive rotation and surgical； Mammary gland hyperplasia； Therapeutic efficacy； Safety |
| 阅读数： | 299 次 |
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