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磷酸奥司他韦颗粒剂联合蒲地蓝消炎口服液治疗儿童流感疑似病例的药物经济学评价
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| 篇名： | 磷酸奥司他韦颗粒剂联合蒲地蓝消炎口服液治疗儿童流感疑似病例的药物经济学评价 |
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| 摘要： | 目的：评价磷酸奥司他韦颗粒剂联合蒲地蓝消炎口服液治疗儿童流感疑似病例的有效性和经济性。方法：采用实际临床试验（PCT）设计方法，将180例儿童流感疑似病例随机分为对照组和试验组，每组90例。对照组口服磷酸奥司他韦颗粒剂，试验组在此基础上加服蒲地蓝消炎口服液。收集患儿的临床效果和成本数据，从患者角度进行成本-效果分析，运用多元线性回归和二元Logistic回归分别对成本和效果进行敏感度分析。结果：实际纳入对照组80例、试验组82例。两组患儿的临床有效率分别是80.00％、95.12％，不良反应发生率、合并用药（除联用抗生素外）、依从性等差异均无统计学意义（P＞0.05）；平均药品成本分别是119.27、171.82元，平均总成本分别是203.46、257.03元；药品的增量成本-效果比（ICER）为347.55，总成本的ICER为354.30。敏感度分析结果与基础分析一致。结论：磷酸奥司他韦颗粒剂联合蒲地蓝消炎口服液治疗儿童流感疑似病例的疗效优于磷酸奥司他韦颗粒剂单用，但是磷酸奥司他韦颗粒剂单用更具有经济性。 |
| ABSTRACT： | OBJECTIVE： To evaluate the effectiveness and economics of Oseltamivir phosphate granules combined with Pudilan xiaoyan oral liquid in the treatment of suspected case of children influenza. METHODS： A pragmatic clinical trial （PCT）was conducted. A total of 180 suspected case of children influenza were randomly divided into control group and trial group， with 90 cases in each group. Control group was given Oseltamivir phosphate granules orally. Trial group was additionally given Pudilan xiaoyan oral liquid on the basis of control group. Clinical effects and cost data of children were collected. Cost-effectiveness analysis was conducted from a point of view of the patient. Sensitivity analysis of cost and effectiveness was conducted by multiple linear regression and binary Logistic regression. RESULTS： Totally 80 cases were included in control group， and 82 cases were included in trial group. The response rates of 2 groups were 80.00％ and 95.12％. There were no statistical significance in the incidence of ADR， drug combination except for combination of antibiotics （P＞0.05）； average drug costs were 119.27 and 171.82 yuan， and average total costs were 203.46 and 257.03 yuan. Incremental cost-effectiveness ratio （ICER） of drug was 347.55 and ICER of total cost was 354.30. The results of sensitivity analysis were consistent with that of basic analysis. CONCLUSIONS： Therapeutic efficacy of Oseltamivir phosphate granules combined with Pudilan xiaoyan oral liquid is better than Oseltamivir phosphate granules alone in the treatment of suspected case of children influenza. But Oseltamivir phosphate granules alone are more economical. |
| 期刊： | 2018年第29卷第13期 |
| 作者： | 陈圣洁，东蕾，蒋春颖，姜海燕，徐梅先 |
| AUTHORS： | CHEN Shengjie，DONG Lei，JIANG Chunying，JIANG Haiyan，XU Meixian |
| 关键字： | 流感；儿童；磷酸奥司他韦颗粒剂；蒲地蓝消炎口服液；成本效果分析 |
| KEYWORDS： | Influenza； Children； Oseltamivir phosphate granules； Pudilan xiaoyan oral liquid； Cost-effectiveness analysis |
| 阅读数： | 879 次 |
| 本月下载数： | 10 次 |
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