我院2005-2017年嗜麦芽窄食单胞菌的临床分布及耐药性分析
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篇名: 我院2005-2017年嗜麦芽窄食单胞菌的临床分布及耐药性分析
TITLE:
摘要: 目的:为临床抗嗜麦芽窄食单胞菌药物的合理选用提供参考。方法:回顾性分析我院2005年1月-2017年12月分离的3 971株嗜麦芽窄食单胞菌的临床分布及耐药情况。结果:我院2005-2017年检出的嗜麦芽窄食单胞菌占检出细菌总数的2.9%(3 971/136 327);该菌检出数量由2005年的129株上升至2017年的468株,占各年检出细菌总数的2.3%~3.4%。该菌主要来源于痰液(3 130株,占78.8%)、脓液+伤口分泌物(213株,占5.4%)、胸腹水(170株,占4.3%)等标本,在脑外科(742株,占18.7%)、重症监护科(538株,占13.5%)、呼吸科(401株,占10.1%)、肝胆科(366株,占9.2%)等科室均有分布。该菌对米诺环素、左氧氟沙星、复方磺胺甲噁唑的耐药率分别由2005年的0、16.5%、14.5%变化至2017年的0.4%、4.0%、2.9%,且对米诺环素的耐药率最低(0~4.6%)。结论:我院各年嗜麦芽窄食单胞菌的检出数量虽有所增加,但其构成比无明显变化。该菌主要分布于脑外科,且以引发呼吸道感染为主。该菌对3种抗菌药物的耐药率总体呈下降趋势,临床可根据药敏试验结果合理选用抗菌药物。
ABSTRACT: OBJECTIVE: To provide reference for rational selection of anti-Stenotrophomonas maltophilia drugs. METHODS: Clinical distribution and drug resistance of 3 971 strains of S. maltophilia were retrospectively analyzed in our hospital during Jan. 2005-Dec. 2017. RESULTS: The constituent ratios of S. maltophilia in total amount of bacteria were 2.9% (3 971/136 327) during 2005-2017. The number of the bacteria increased from 129 strains in 2005 to 468 strains in 2017, accounting for 2.3%-3.4% in total amount of bacteria. S. maltophilia mainly came from sputum (3 130 strains, 78.8%), fester+wound secretion (213 strains, 5.4%), pleural effusion and ascites (170 strains, 4.3%), and they were distributed in cerebral surgery department (742 strains, 18.7%),ICU (538 strains, 13.5%),respiratory department (401 strains, 10.1%) and hepatobiliary surgery department (366 strains, 9.2%), etc. Drug resistance rate of the bacteria to minocycline, levofloxacin and Compound sulfamethoxazole changed from 0, 16.5%, 14.5% in 2005 to 0.4%, 4.0%, 2.9% in 2017, respectively; S. maltophilia had the lowest resistant to minocyclin (0-4.6%). CONCLUSIONS: The amount of S. maltophilia in our hospital increased in each year, but its constituent ratio does not change significantly. Most of S. maltophilia are isolated from cerebral surgery department, and dominantly cause respiratory tract infection. The resistance rate of the bacteria to 3 kinds of antibiotics decreases generally, and antibiotics could be reasonably selected according to the results of drug sensitivity test.
期刊: 2018年第29卷第16期
作者: 熊丽蓉,冯伟,向荣凤,喻明洁,孙凤军
AUTHORS: XIONG Lirong,FENG Wei,XIANG Rongfeng,YU Mingjie,SUN Fengjun
关键字: 嗜麦芽窄食单胞菌;临床分布;耐药性;抗菌药物
KEYWORDS: Stenotrophomonas maltophilia; Clinical distribution; Drug resistance; Antibiotics
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