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非洛地平缓释片（Ⅱ）对比硝苯地平缓释片控制围绝经期高血压患者血压晨峰现象的临床观察
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| 篇名： | 非洛地平缓释片（Ⅱ）对比硝苯地平缓释片控制围绝经期高血压患者血压晨峰现象的临床观察 |
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| 摘要： | 目的：观察并比较非洛地平缓释片（Ⅱ）与硝苯地平缓释片控制围绝经期高血压患者血压晨峰现象的效果。方法：将2015年1月－2018年5月我院232例围绝经期高血压病且存在血压晨峰现象患者随机分为观察组与对照组，观察组患者口服非洛地平缓释片（Ⅱ）5 mg/次，每晚1次；对照组患者口服硝苯地平缓释片20 mg/次，每日2次。分别记录两组患者治疗1、2、3、4周后的舒张压、收缩压及血压晨峰值，并比较两组患者治疗4周后的临床疗效及不良反应的发生情况。结果：观察组和对照组排除不遵医嘱者、失访者后有效例数分别为94、98例。治疗前，两组患者舒张压、收缩压及血压晨峰值比较差异无统计学意义（P＞0.05）；治疗1周后，观察组患者舒张压显著低于对照组（P＜0.05）；治疗2周后，观察组患者血压晨峰值显著低于对照组（P＜0.05）；治疗3周后，观察组患者收缩压、舒张压及血压晨峰值均显著低于对照组（P＜0.05）；治疗4周后，观察组患者收缩压、舒张压及血压晨峰值均显著低于对照组（P＜0.05），且达到正常值；观察组患者治疗总有效率（96.80％）显著高于对照组（84.69％）（P＜0.05）；观察组患者不良反应发生率（3.19％）显著低于对照组（13.27％）（P＜0.05）。结论：非洛地平缓释片对围绝经期高血压患者血压晨峰现象的控制效果较好，可为临床用药提供参考。 |
| ABSTRACT： | OBJECTIVE： To observe and compare the efficacy of Felodipine sustained-release tablets （Ⅱ） and Nifedipine sustained-release tablets for morning blood pressure surge control in peri-menopausal hypertension patients. METHODS： A total of 232 peri-menopausal hypertensive patients with morning blood pressure surge in our hospital from Jan. 2015 to May 2018 were randomly divided into observation group and control group. Observation group received Felodipine sustained-release tablet （Ⅱ） orally 5 mg/time， once every night. Control group received Nifedipine sustained-release tablet orally 20 mg/time， twice a day. The diastolic blood pressure， systolic blood pressure and the number of morning blood pressure surge were recorded in 2 groups after 1， 2， 3， 4 weeks of treatment. The therapeutic effects and ADR of 2 groups were compared after 4 weeks of treatment. RESULTS： There were 94 and 98 effective cases in observation group and control group after excluding the patients who didn’t obey the doctor’s advice or those who failed to follow up. Before treatment， there was no statistical significance in diastolic blood pressure， systolic blood pressure or the number of morning blood pressure surge between 2 groups （P＞0.05）. After one week of treatment， diastolic blood pressure of observation group was significantly lower than that of control group （P＜0.05）. After two weeks of treatment， the number of morning blood pressure surge of observation group was significantly lower than that of control group （P＜0.05）. After 3 weeks of treatment， diastolic blood pressure， systolic blood pressure and the number of morning blood pressure surge in observation group were significantly lower than control group （P＜0.05）. After 4 weeks of treatment， diastolic blood pressure， systolic blood pressure and the number of morning blood pressure surge in observation group were significantly lower than control group （P＜0.05）， and reached normal level. Total response rate of observation group （96.80％） was significantly higher than that of control group （84.69％） （P＜0.05）； the incidence of ADR in observation group （3.19％） was significantly control group （13.27％） （P＜0.05）. CONCLUSIONS： Felodipine sustained-release tablet shows excellent control effect on morning blood pressure surge in peri-menopausal hypertension patients， which provide reference for drug use in clinic. |
| 期刊： | 2018年第29卷第21期 |
| 作者： | 刘东升，韩海莉，张军 |
| AUTHORS： | LIU Dongsheng，HAN Haili，ZHANG Jun |
| 关键字： | 围绝经期；高血压；血压晨峰；非洛地平缓释片（Ⅱ）；硝苯地平缓释片 |
| KEYWORDS： | Peri-menopause； Hypertension； Morning blood pressure surge； Felodipine sustained-release tablet （Ⅱ）； Nifedipine sustained-release tablets |
| 阅读数： | 500 次 |
| 本月下载数： | 5 次 |
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