基于数据挖掘的抗胃癌植物类中药组方设计-中国药房

基于数据挖掘的抗胃癌植物类中药组方设计

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篇名：	基于数据挖掘的抗胃癌植物类中药组方设计
TITLE：
摘要：	目的：为临床抗胃癌中药组方设计及新药研发提供参考。方法：通过检索《中国药典（一部）》（2015年版）、《中药学》（第4版）以及PubMed、中国知网、维普等国内外数据库，对抗胃癌植物类中药的品种、抗肿瘤机制、性味归经特点以及肠道微生态环境的影响因素等信息进行挖掘、整理，并结合肿瘤分期进行抗胃癌植物类中药的组方设计。结果与结论：明确有抗胃癌活性的植物类中药共85种，其抗肿瘤机制以抑制增殖/生长、调节免疫、诱导凋亡、抑制侵袭/转移为主，丰度分别为0.741、0.718、0.447、0.271；药性以寒、温、平为主，丰度分别为0.424、0.282、0.200；药味以苦、甘、辛为主，丰度分别为0.612、0.518、0.271；归经以肝、肺、肾、脾经为主，丰度分别为0.553、0.424、0.376、0.365；主要涉及品种包括太子参、胡颓子叶、人参、黄芩、黄连、白花蛇舌草、缬草等。微生态制剂的使用、饮食习惯的改善、毒性应激的减少以及补虚、清热、消食类中药（如党参、山药、熟地黄、蒲公英、山楂等）的应用均会对肠道微生态环境的平衡产生有利影响。临床应按照“目标调节+整体调节+肠道微生态环境调节”的规则进行组方设计，其中胃癌早期宜以抑制增殖/生长为主，应选择性寒、凉，味辛、甘，归肝、心经的植物类中药；胃癌中期宜以抑制侵袭/转移为主，应选择性平、凉、温，味甘、苦、辛，归胃、脾、肝、肺经的植物类中药；胃癌晚期宜以调节免疫和诱导凋亡为主，应选择性温、平，味苦、甘、酸，归肾、肺、脾、胃经的植物类中药；同时辅以具肠道微环境调节作用的植物类中药，结合中医辨证和患者病情特征进行个体化组方，以充分发挥中药对胃癌的治疗作用。
ABSTRACT：	OBJECTIVE： To provide reference for the design of TCM formula for gastric cancer （GC） and new drug research and development. METHODS： Retrieved from Chinese Pharmacopeia （part Ⅰ）（2015 edition）， Chinese Materia Medica （4th edition）， PubMed， CNKI， VIP and other databases， plant-based TCM for GC， antineoplastic mechanism， property， taste， channel tropism and influential factors of intestinal microecology were mined and summarized. The plant-based TCM formula for GC was designed according to tumor staging. RESULTS & CONCLUSIONS： It was clear that there were 85 kinds of plant-based TCM for anti-GC activity. The main anti-tumor mechanisms were inhibiting proliferation/growth， regulating immunity， inducing apoptosis and inhibiting invasion/metastasis， with the abundance of 0.741， 0.718， 0.447 and 0.271， respectively. The main properties of TCM were cold， warm and flat， with the abundance of 0.424， 0.282 and 0.200， respectively. The main tastes of TCM were bitter， sweet and spicy， with the abundance of 0.612， 0.518， 0.271， respectively. The main channel tropisms were liver， lung， kidney and spleen， with the abundance of 0.553， 0.424， 0.376， 0.365， respectively. Main types involved were Pseudostellaria heterophylla， Elaeagnus pungens， Panax ginseng， Scutellaria baicalensis， Coptis chinensis， Hedyotis diffusa， Valeriana officinalis， etc. The application of microecological preparation， the improvement of eating habits， the reduction of toxic stress， the application of TCM for nourishing deficiency， clearing away heat and helping to digest （Codonoposis radix， Dioscoreae rhizome， Rehmannia glutinosa， Taraxacum mongolicum， Crataegus pinnatifida， etc.） had beneficial effects on the balance of intestinal microecology. The formula was designed according to the rules of “target regulation+overall regulation+regulation of intestinal microecology”. For early GC， it is suitable to mainly inhibit proliferation/growth， and choose plant-based TCM with cold property， spicy and sweet taste， acting on liver and heart channel. For medium-term GC， it is suitable to mainly inhibit invasion/metastasis， and choose plant-based TCM with flat， cold and warm property， sweet， bitter and spicy taste， acting on stomach， spleen， liver and lung channel. For advanced GC， it is suitable to mainly regulate immunity and induce apoptosis， and choose plant-based TCM with warm and flat property， bitter， sweet and sour taste， acting on kidney， lung， spleen and stomach channel. Additionally plant-based TCM with regulation of intestinal microecology is used and individual formula based on TCM syndrome differentiation and patient’s condition is adopted so as to give full play to therapeutic effect on GC.
期刊：	2018年第29卷第24期
作者：	蒋先仲，郭红莲
AUTHORS：	JIANG Xianzhong， GUO Honglian
关键字：	抗胃癌；植物类中药；中药组方设计；抗肿瘤机制；性味归经；肠道微生态环境；丰度；数据挖掘
KEYWORDS：	Anti-gastric cancer； Plant-based TCM； TCM formula design； Anti-tumor mechanism； Tropism of taste； Intestinal microecology； Abundance； Data mining
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