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临床药师利用证据质量评价方法制订我院疏血通注射液临床应用规范的实践
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| 篇名： | 临床药师利用证据质量评价方法制订我院疏血通注射液临床应用规范的实践 |
| TITLE： | |
| 摘要： | 目的：为加强重点监控药物的临床使用管理和促进临床合理用药提供参考。方法：介绍怀化市第一人民医院（简称我院）临床药师以循证医学为基础，以重点监控药物疏血通注射液为例，全面检索其在国内外临床研究中的临床证据，将纳入文献参照GRADE证据质量分级和推荐强度系统进行分级，评价疏血通注射液各适应证的循证医学证据，制订我院疏血通注射液的临床应用规范的实践。结果：我院制订的疏血通注射液临床应用规范的主要内容为用于急性缺血性脑梗死时有A级证据支持，但为弱推荐，仅用于辅助治疗；用于抗凝（预防深部静脉血栓形成）、糖尿病周围神经病变时有B级证据支持，为弱推荐；用于其他适应证时只有C级或D级证据支持，为反对使用的强推荐。结论：临床药师通过证据质量评价方法制订药物的临床应用规范，可为重点监控药物的临床使用管理提供参考，可在临床合理用药中发挥重要作用。 |
| ABSTRACT： | OBJECTIVE： To provide reference for strengthening clinical application of key monitoring drugs and promoting rational drug use in clinic. METHODS： Based on evidence-based medicine， taking key monitoring drugs Shuxuetong injection as example， clinical evidence of domestic and foreign clinical studies were collected. The included literatures were graded according to the quality of GRADE evidence and recommended strength system. Evidence-based medicine evidence for the indications of Shuxuetong injection were evaluated， and criterion for clinical use of Shuxuetong injection was formulated in Huaihua First People’s Hospital （our hospital）. RESULTS： The main content of criterion for clinical application of Shuxuetong injection formulated by our hospital was that there was A-level evidence support for acute ischemic cerebral infarction， but it was weakly recommended and only used for adjuvant therapy； there was B-level evidence support for anticoagulation （for preventing DVT）， diabetic peripheral nerve lesion， but it was weakly recommended； there was only C-level or D-level evidence support for other indications， it was strongly recommendation against use. CONCLUSIONS： Clinical pharmacists formulate the criterion for clinical application of Shuxuetong injection by evidence quality evaluation method， provide reference for clinical application management of key monitoring drug and play an important effect on rational drug use in clinic. |
| 期刊： | 2019年第30卷第11期 |
| 作者： | 邓紫薇，邓晔，金远香，仇成凤，王宏强，谭力铭，史志华 |
| AUTHORS： | DENG Ziwei，DENG Ye，JIN Yuanxiang，QIU Chengfeng，WANG Hongqiang，TAN Liming，SHI Zhihua |
| 关键字： | 重点监控药物；疏血通注射液；临床药师；证据质量评价；临床用药规范 |
| KEYWORDS： | Key monitoring drugs； Shuxuetong injection； Clinical pharmacist； Evidence quality evaluation； Criterion for clinical medication |
| 阅读数： | 426 次 |
| 本月下载数： | 15 次 |
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