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中医辨证个体化疗法治疗胃癌前病变的临床观察
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| 篇名： | 中医辨证个体化疗法治疗胃癌前病变的临床观察 |
| TITLE： | |
| 摘要： | 目的：为临床治疗胃癌前病变提供参考。方法：选择2018年1－12月在我院治疗的胃癌前病变患者共685例，其中治疗组455例患者采用中医辨证的个体化中医药物治疗，7 d为1个疗程，共治疗4个疗程；对照组230例患者接受叶酸片治疗，每次5 mg，tid，连续用药2个月。比较两组患者接受治疗前后胃蛋白酶原比值（PGⅠ/PGⅡ）、胃泌素17（G-17）、幽门螺杆菌（Hp）水平的变化情况，以及相关不良反应的发生情况。结果：治疗后，治疗组患者总有效率为90.3％，显著高于对照组的68.6％；治疗组患者的PGⅠ/PGⅡ较治疗前显著上升，且显著高于对照组；两组患者的G-17水平均较治疗前显著下降（P＜0.05），而两组患者Hp水平治疗前后比较差异无统计学意义（P＞0.05）。两组患者不良反应发生率比较，差异无统计学意义（P＞0.05）。结论：中医辨证个体化治疗方案可显著延缓胃癌前病变的发展，且安全性良好。 |
| ABSTRACT： | OBJECTIVE： To provide reference for clinical treatment of precancerous lesions of gastric cancer. METHODS： A total of 685 patients with precancerous lesions of gastric cancer were selected from our hospital during Jan.-Dec. 2018. Totally 455 patients in treatment group received individualized TCM therapy according to syndrome differentiation， 7 days as a course， 4 courses in total； another 230 patients in control group received Folic acid tablets， 5 mg， tid， for 2 months. The changes of pepsinogen ratio （PGⅠ/PGⅡ）， gastrin-17 （G-17） and Helicobacter pylori （Hp）before and after treatment， and the occurrence of ADR were compared between 2 groups. RESULTS： After treatment， total response rate of treatment group was 90.3％， which was significantly higher than 68.6％ of control group. PGⅠ/PGⅡ of treatment group were increased significantly， which was significantly higher than control group； G-17 levels of 2 groups were decreased significantly （P＜0.05）； there was no statistical significance in Hp level between 2 groups before and after treatment （P＞0.05）. There was no statistical significance in the incidence of ADR between 2 groups（P＞0.05）. CONCLUSIONS： Chinese medicine syndrome differentiation individual therapy can significantly delay the development of precancerous lesions of gastric cancer， and has good safety. |
| 期刊： | 2019年第30卷第24期 |
| 作者： | 梁静秋，谭婧宇，陈琪，王维，张海燕 |
| AUTHORS： | LIANG Jingqiu，TAN Jingyu，CHEN Qi，WANG Wei，ZHANG Haiyan |
| 关键字： | 中医辨证；胃癌前病变；胃蛋白酶原比；胃泌素17；幽门螺杆菌 |
| KEYWORDS： | Chinese medicine syndrome differentiation； Precancerous lesion of gastric cancer； Pepsinogen ratio； Gastrin-17； Helicobacter pylori |
| 阅读数： | 320 次 |
| 本月下载数： | 8 次 |
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