目的：评价两种治疗慢性乙型肝炎肝纤维化方案的成本-效果。方法：选择112 例慢性乙型肝炎肝纤维化患者随机分成

复方鳖甲软肝片组（A组）和安络化纤丸组（B组）各56 例，两组患者分别服用恩替卡韦分散片联合相应的中成药。分别在治疗

前后检测两组患者的肝纤维化指标、瞬时弹性成像，进行中医证候评分，计算有效率，比较两种方案的成本-效果。结果：A组方

案的成本为9 227.10 元，有效率为74.11％，成本-效果比为12 451；B组方案的成本为8 202.90 元，有效率为69.28％，成本-效果比

为11 840；增量成本-效果比为21 205。B组方案具有较好的成本-效果。敏感度分析结果与成本-效果分析结果一致。结论：安络

化纤丸联合恩替卡韦治疗慢性乙型肝炎肝纤维化的成本-效果优于复方鳖甲软肝片联合恩替卡韦。

OBJECTIVE：To analyze the cost-effectiveness of two regimens in the treatment of chronic hepatitis B fibrosis.

METHODS：112 cases of chronic hepatitis B fibrosis were divided into Compound biejia ruangan tablet group（group A，n＝56）

and Anluo huaxian pill group（group B，n＝56）. Both groups received Entecavir dispersible tablets combined with relevant Chinese

patent medicine. The liver fibrosis index and transient elastography of 2 group were detected before and after treatment，TCM symptom

score and effective rate calculation were conducted to compare the cost-effectiveness of 2 groups. RESULTS：The cost，effective

rate and cost-effectiveness ratio of group A were 9 227.10 yuan，74.11％ and 12 451；those of group B were 8 202.90 yuan，

69.28％ and 11 840；incremental cost-effectiveness ratio was 21 205. Group B showed a better cost-effectiveness. Result of sensitivity

test was same to that of cost-effectiveness analysis. CONCLUSIONS：The cost-effectiveness of Anluo huaxian pill combined

with Entecavir dispersible tables is better than Compound biejia ruangan tablet combined with Entecavir dispersible tables in the

treatment of chronic hepatitis B fibrosis.