目的：了解我院药品不良反应（ADR）发生的规律及特点，为临床合理用药提供参考。方法：收集郑州人民医院2013－

2014 年上报国家ADR监测中心的368 例ADR报告，从患者性别、年龄、给药途径、ADR涉及的药品种类、ADR累及器官/系统及其

临床表现、ADR转归等方面进行统计、分析。结果：368 例ADR中，女性多于男性（52.99％ vs. 47.01％）；50 岁以上患者ADR发生

例数最多（占36.14％）；引发ADR的药物以抗菌药物、中药制剂居多，分别占40.22％、21.47％；给药途径中静脉注射引发的ADR

最多（占85.60％）；临床表现以皮肤及其附件损害最多，其次是消化系统，分别占39.95％、21.47％。所有ADR患者经停用相关药

物后均治愈或好转，无死亡病例。结论：临床应加强ADR监测和分析评价工作，加强抗菌药物和中药注射剂临床使用管理，并采

取各种措施降低药品风险。

OBJECTIVE：To explore regularity and characteristics of ADR in our hospital，and to provide reference for rational

drug use in the clinic. METHODS：A total of 368 ADR collected from Zhengzhou People’s Hospital during 2013-2014 were analyzed

statistically in respects of patient’s gender，age，drug types，route of administration，dosage form，organs or systems involved

in ADR，clinical manifestations，ADR outcome，etc. RESULTS：Of 368 ADR reports，female was more than male

（52.99％ vs. 47.01％）；the number of patients aged more than 50 years was the most（36.14％）；most of ADR cases were induced

by antibiotics and TCM preparations，accounting for 40.22％，21.47％，respectively；among route of administration，most of ADR

cases were induced by intravenous administration（85.60％）；main clinical manifestations were lesion of skin and its appendants

（39.95％），followed by digestive system （21.47％）. After treatment，all patients were cured or improved，no death case was

found. CONCLUSIONS：Clinic should strengthen ADR monitoring and analysis and evaluarion，strengthen the rational use of antibiotics

and TCM injections and adopt measures to reduce drug risk.