请在关注微信后,向客服人员索取文件
篇名: | 血浆置换不同补充时机对药物性肝损伤疗效的影响 |
TITLE: | |
摘要: | 目的:探讨血浆置换不同补充时机对药物性肝损伤疗效的影响。方法:96 例药物性肝损伤患者,按照随机数字表法分为 A、B、C组,各32 例。所有患者在常规治疗基础上进行血浆置换治疗。其中,A组患者与血浆置换同步进行的替补液为100%新鲜 血浆;B组患者与血浆置换同步进行的替补液为:先补充40%生理盐水,再补充60%新鲜血浆;C组患者在血浆置换至离体血液达 1 个体循环量的12%时,再开始补充替补液,补充顺序为先补充40%生理盐水,再补充60%新鲜血浆。观察各组患者治疗前后的 临床症状及体征、肝脏功能和凝血酶原活动度。结果:采用血浆置换治疗药物性肝损伤均可获得较好的疗效,但C组患者临床症 状及体征消失的时间显著短于A组和B组,B组又显著短于A组,组间比较差异均具有统计学意义(P<0.05)。3 组患者治疗后的 总胆红素、凝血酶原活动度、白蛋白水平均显著优于治疗前,差异具有统计学意义(P<0.05),且C组优于A、B两组,B组优于A 组,组间比较差异均具有统计学意义(P<0.05)。3 组患者治疗后的丙氨酸转氨酶和天冬氨酸转氨酶水平显著下降,与治疗前比较 差异具有统计学意义(P<0.05),且B、C组显著优于A组,差异具有统计学意义(P<0.05),而B、C两组相似,差异无统计学意义 (P>0.05)。结论:在不同时机进行血浆置换对药物性肝损伤有着不同的疗效,在血浆置换至离体血液达1 个体循环量的12%时, 先补充40%生理盐水,再补充60%新鲜血浆的效果较为显著。 |
ABSTRACT: | OBJECTIVE:To explore the effect of different plasmapheresis supplement timing on therapeutic efficacy of toxic liver injury. METHODS:96 patients with toxic liver injury and divided into group A,B ,C and D with 32 cases in each group according to different plasmapheresis supplement timing. All patients received plasmapheresis supplement based on routine treatment. In group A,synchronized fluid replacement was 100% fresh plasma;in group B,synchronized fluid replacement was 40% normal saline firstly,and then 60% fresh plasma;in group C,substitute liquid was given till the in vitro blood reached 12% of circulation amount,supplement order as 40% normal saline for the first supplement,and then add 60% fresh plasma. The clinical symptoms and signs,liver function,prothrombin activity and blood biochemical indicators were observed in each group before and after treatment. RESULTS:Plasmapheresis supplement had good therapeutic efficacy on toxic liver injury;but the time of clinical symptoms and signs disappearance in group C was significantly shorter than that in group A and B,and the group B was significantly shorter the group A,with statistical significance(P<0.05). The plasma bilirubin,prothrombin activity,albumin levels of 3 groups after treatment were significantly better than before,with statistical significance(P<0.05);the group C was better than the group A and B,and the group B was better than the group A,with statistical significance(P<0.05). Compared with before treatment,the levels of AST and ALT in 3 groups decreased significantly after treatment,with statistical significance(P<0.05);the group B and C were better than the group A,with statistical significance(P<0.05);the group B and C was similar to each other,without statistical significance(P>0.05). CONCLUSIONS:Different plasmapheresis supplement timing have different effect on toxic liver injury. The supplement method that giving 40% normal saline for the first supplement,and then add 60% fresh plasma when in vitro blood reach 12% of circulation amount has more significant effect. |
期刊: | 2015年第26卷第35期 |
作者: | 秦海珍,陈绪军 |
AUTHORS: | QIN Hai-zhen,CHEN Xu-jun |
关键字: | 药物性肝损伤;血浆置换;时机;替补液 |
KEYWORDS: | Toxic liver injury;Plasmapheresis supplement;Timing;Fluid replacement |
阅读数: | 301 次 |
本月下载数: | 1 次 |
* 注:未经本站明确许可,任何网站不得非法盗链资源下载连接及抄袭本站原创内容资源!在此感谢您的支持与合作!