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篇名: | 肝动脉灌注化疗栓塞联合高强度聚焦超声治疗中晚期原发性肝 |
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摘要: | 目的:观察肝动脉灌注化疗栓塞(TACE)联合高强度聚焦超声(HIFU)治疗中晚期原发性肝癌的疗效及安全性。方法:76 例中晚期原发性肝癌患者,按随机数字表法分成治疗组36 例和对照组40 例。对照组患者单纯采用TACE治疗,治疗组患者于 TACE后2~3 周加用HIFU治疗。比较两组患者的临床疗效、手术前后甲胎蛋白(AFP)含量、生存率、生存期及不良反应。结果: 治疗组患者的显效率和总有效率分别为61.1%、94.4%,均显著高于对照组(35.0%、77.5%),差异有统计学意义(P<0.05)。两组 患者治疗后的AFP含量均较治疗前显著下降,差异有统计学意义(P<0.05),组间比较差异也有统计学意义(P<0.05)。治疗组患 者在术后24、36 个月的生存率均高于对照组,差异有统计学意义(P<0.05)。治疗组患者的中位生存期为11.3 个月,长于对照组的 9.2 个月,但组间比较差异无统计学意义(P>0.05)。两组患者均未发生严重不良反应。结论:相较于单纯TACE,TACE联合HIFU 治疗中晚期原发性肝癌能提高患者远期生存率和近期疗效,且安全性较好。 |
ABSTRACT: | OBJECTIVE To observe therapeutic efficacy and safety of transcatheter arterial chemoembolization(TACE)combined with high intensity focused ultrasound (HIFU) in the treatment of middle and advanced primary hepatocellular carcinoma (HCC). METHODS:76 patients with middle and advanced primary HCC were randomly divided into treatment group(36 cases) and control group(40 cases). Control group was given TACE alone,and treatment group was additionally given HIFU 2-3 weeks after TACE. Clinical efficacy,the content of alpha-fetoprotein(AFP)before and after operation,survival rate,survival period and ADR were compared between 2 groups. RESULTS:The efficiency rate and total effective rate of treatment group were 61.1% and 94.4%,which were significantly higher than those of control group(35.0%,77.5%),with statistical significance(P<0.05). The content of AFP in 2 groups decreased significantly after operation,with statistical significance(P<0.05);there also was statistical significance between 2 groups(P<0.05). Survival rate of treatment group was higher than that of control group 24 and 36 months after operation,with statistical significance (P<0.05). The median survival time was 11.3 months in treatment group and 9.2 month in control group,with no statistical difference(P>0.05). No obvious ADR was found in 2 groups. CONCLUSIONS:Compared with TACE alone,TACE combined with HIFU in the treatment of middle and advanced primary HCC can improve long-term survival rate and the short-term efficacy,with good safety. |
期刊: | 2015年第26卷第35期 |
作者: | 付斯瑜,任汝仙,王美江,陈奕霖,蒋保华,张琴 |
AUTHORS: | FU Si-yu,REN Ru-xian,WANG Mei-jiang,CHEN Yi-lin,JIANG Bao-hua,ZHANG Qin |
关键字: | 肝动脉灌注化疗栓塞;高强度聚焦超声;中晚期肝癌;疗效;安全性 |
KEYWORDS: | Hepatic arterial chemoembolization;High intensity focused ultrasound;Middle and advanced hepatocellular carcinoma; |
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