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复方甘草酸苷联合阿昔洛韦治疗小儿传染性单核细胞增多症的临床观察
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| 篇名： | 复方甘草酸苷联合阿昔洛韦治疗小儿传染性单核细胞增多症的临床观察 |
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| 摘要： | 目的：观察复方甘草酸苷联合阿昔洛韦治疗小儿传染性单核细胞增多症的疗效和安全性。方法： 90例小儿传染性单核细胞增多症患儿随机均分为对照组和研究组。对照组患者给予阿昔洛韦注射液 10 mg/（kg·d），加入5％葡萄糖注射液150 ml中，静脉滴注，每日2次；研究组患儿在对照组治疗的基础上给予复方甘草酸苷注射液2～4 ml/kg，加入5％葡萄糖注射液150 ml中，静脉滴注，每日2次。两组患儿疗程均为2周。观察两组患儿的临床疗效，住院时间和各临床症状改善时间，治疗前后T淋巴细胞亚群（CD3+、CD4+、CD8+、CD4+/CD8+）及不良反应发生情况。结果：研究组患儿总有效率显著高于对照组，住院时间和各临床症状改善时间均显著短于对照组，差异均有统计学意义（P＜0.05）；治疗后，两组患儿CD3+、CD8+均显著低于同组治疗前，且研究组低于对照组， CD4+、CD4+/CD8+均显著高于同组治疗前，且研究组高于对照组，差异均有统计学意义（P＜0.05）。两组患儿不良反应发生率比较，差异无统计学意义（P＞0.05）。结论：复方甘草酸苷联合阿昔洛韦治疗小儿传染性单核细胞增多症较单用阿昔洛韦疗效更显著，安全性相当。 |
| ABSTRACT： | OBJECTIVE：To observe the clinical efficacy and safety of compound glycyrrhizin combined with acyclovir in the treatment of children with infectious mononucleosis. METHODS： 90 children with infectious mononucleosis were randomly divided into control group and research group. Control group was given Acyclovir injection 10 mg/（kg·d） adding into 150 ml 5％ Glucose solution by intravenous infusion， twice a day. Research group was additionally given Compound glycyrrhizin injection 2-4 ml/kg， adding into 150 ml 5％ Glucose solution by intravenous infusion， twice a day. The treatment course for both group was 2 weeks. Clinical efficacy， hospitalization time， improvement time of clinical symptoms，T lymphocyte subsets （CD3+，CD4+，CD8+ and CD4+/CD8+） before and after treatment and incidence of adverse reactions in 2 groups were observed. RESULTS： The total effective rate in research group was significantly higher than control group， hospitalization time and improvement time of clinical symptoms were significantly better than control group， the differences were statistically significant（P＜0.05）. After treatment， CD3+ and CD8+ were significantly lower than before， and research group was lower than control group， CD4+ and CD4+/CD8+ were significantly higher than before， and research group was higher than before， the differences were statistically significant（P＜0.05）. There was no significant difference in the incidence of adverse reactions between 2 groups（P＞0.05）. CONCLUSIONS： Compound glycyrrhizin combined with acyclovir has better efficacy than only acyclovir in the treatment of children with infectious mononucleosis， with similar safety. |
| 期刊： | 2015年第26卷第36期 |
| 作者： | 张其相，张建华 |
| AUTHORS： | ZHANG Qi-xiang，ZHANG Jian-hua |
| 关键字： | 传染性单核细胞增多症；复方甘草酸苷；阿昔洛韦；疗效；安全性 |
| KEYWORDS： | Infectious mononucleosis； Compound glycyrrhizin； Acyclovir； Efficacy； Safety |
| 阅读数： | 352 次 |
| 本月下载数： | 0 次 |
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