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莫西沙星联合结核丸治疗耐多药肺结核的临床观察
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| 篇名： | 莫西沙星联合结核丸治疗耐多药肺结核的临床观察 |
| TITLE： | |
| 摘要： | 目的：观察莫西沙星联合结核丸治疗耐多药肺结核的疗效和安全性。方法：116例耐多药肺结核患者随机均分为对照组和观察组。对照组患者给予盐酸莫西沙星片0.4 g，口服，每日1次；观察组患者在对照组治疗的基础上给予结核丸9 g，口服，每日2次。同时两组患者均给予利福喷丁、丙硫异烟肼、阿米卡星、帕司烟肼、吡嗪酰胺、对氨基水杨酸等常规药物治疗。两组患者疗程均为18个月。观察两组患者的临床疗效，治疗前及治疗6、12、18个月后的T细胞亚群（CD3+、CD4+、CD4+/CD8+）、干扰素（INF）γ、白细胞介素（IL）4水平及不良反应发生情况。结果：观察组患者总有效率显著高于对照组，差异有统计学意义（P＜0.05）。治疗后，两组患者CD3+、CD4+、CD4+/CD8+、INF-γ水平均显著高于同组治疗前，且随时间逐渐升高，观察组高于对照组；IL-4水平显著低于同组治疗前，且随时间逐渐降低，观察组低于对照组，差异均有统计学意义（P＜0.05）。两组患者不良反应发生率比较，差异无统计学意义（P＞0.05）。结论：在常规治疗的基础上，莫西沙星联合结核丸治疗耐多药肺结核的疗效显著优于单用莫西沙星，且安全性相当。 |
| ABSTRACT： | OBJECTIVE： To observe the efficacy and safety of moxifloxacin combined with Jiehe pill in the treatment of muilt drug-resistant tuberculosis （MDR-TB）. METHODS： 116 patients with MDR-TB were randomly divided into control group and observation group. Control group was given Moxifloxacin hyohochloride tablet 0.4 g once a day，observation group was additionally given Jiehe pill 9 g， twice a day，and 2 groups were given rifapentine， albendazole isoniazid， amikacin， pasiniazide， pyrazinamide， p-amino salicylic acid and other conventional treatment. The treatment course for both groups was 18 months. The clinical efficacy， and T cell subsets （CD3+，CD4+，CD4+/CD8+），interferon（INF）γ，interleukin（IL）4 levels before and after 6， 12 and 18 months， and incidence of adverse reactions in 2 groups were recorded. RESULTS：The total effective rate in observation group was significantly higher than control group， the difference was statistically significant（P＜0.05）. After treatment， CD3+，CD4+，CD4/CD8 and INF-γ level in 2 groups were significantly higher than before and gradually increased by time， and observation group was higher than control group； IL-4 level was significantly lower than before and graually decreased by time， and observation group was lower than control group， the differences were statistically significant（P＜0.05）. There was no significant difference in the incidence of adverse reactions（P＞0.05）. CONCLUSIONS：Based on the coventional treatment， moxifloxacin combined with Jiehe pill has better efficacy than moxifloxacin in the treatment of MDR-TB，with similar safety. |
| 期刊： | 2015年第26卷第36期 |
| 作者： | 史敏双，翁春霞，项辉，王国美 |
| AUTHORS： | SHI Min-shuang，WENG Chun-xia，XIANG Hui，WANG Guo-mei |
| 关键字： | 莫西沙星；结核丸；免疫功能；耐多药肺结核 |
| KEYWORDS： | Moxifloxacin； Jiehe pill； Immune function； Multidrug-resistant tuberculosis |
| 阅读数： | 435 次 |
| 本月下载数： | 0 次 |
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