目的：建立益胃颗粒的质量标准。方法：采用薄层色谱（TLC）法对制剂中黄连、延胡索、五味子进行定性鉴别；采用高效

液相色谱法测定制剂中芍药苷的含量。色谱柱为XDB C18，流动相为甲醇-水（25 ∶75，V/V），流速为1.0 ml/min，检测波长为230

nm，进样量为20 μl。结果：TLC 图斑点清晰，分离度好。芍药苷检查质量浓度线性范围为7.575～60.6 μg/ml（r＝0.999 9）；精密

度、稳定性、重复性试验的RSD＜2.0％；加样回收率96.97％～102.51％，RSD为1.92％（n＝9）。结论：本方法操作简便，重复性好，

可用于益胃颗粒的质量控制。

OBJECTIVE：To establish the quality standard for Yiwei granule. METHODS：TLC was conducted for the qualitative

identification of Coptis chinensis，Corydalis yanhusuo and Schisandra chinensis；HPLC was conduced for the content determination of

paeoniflorin. The column was XDB C18 with mobile phase of methanol-water（25 ∶75，V/V）at flow rate of 1.0 ml/min，detection wavelength

was 230 nm and injection volume was 20 μl. RESULTS：The TLC showed clear spots and good separation. The linear range of

paeoniflorin was 7.575-60.6 μg/ml（r＝0.999 9）；RSDs of precision，stability and reproducibility tests were lower than 2.0％，recovery

was 96.97％-102.51％（RSD＝1.92％，n＝9）. CONCLUSIONS：The method is simple and reproducible，and can be used for the

quality control of Yiwei granule.