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抗抑郁药物治疗卒中后抑郁系统评价/Meta分析的方法学再评价研究
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| 篇名： | 抗抑郁药物治疗卒中后抑郁系统评价/Meta分析的方法学再评价研究 |
| TITLE： | Study on Methodology Re-evaluation for Systematic Review/Meta-analysis of Antidepressants in the Treatment of Post-stroke Depression |
| 摘要： | 目的：对已经发表的抗抑郁药物治疗卒中后抑郁的系统评价/Meta分析进行方法学质量再评价。方法：计算机检索Cochrane图书馆、PubMed、Embase、SinoMed、中国知网、万方数据、维普网、中国生物医学文献数据库等数据库，检索时限均为建库起至2019年12月，收集抗抑郁药物治疗卒中后抑郁的系统评价/Meta分析。筛选文献、提取资料后，采用AMSTAR量表评价纳入文献的方法学质量。结果：共纳入33篇系统评价/Meta分析，共523项随机对照试验，涉及41020例患者。AMSTAR方法学质量评分平均得分为6.76分。西酞普兰、度洛西汀、帕罗西汀等对卒中后抑郁治疗有效，但药物间有效性结论并不一致；帕罗西汀不良反应发生率较低；舍曲林和西酞普兰改善患者神经功能缺损情况尚不明确。结论：抗抑郁药物治疗卒中后抑郁的系统评价/Me-ta分析方法学质量中等，且各种药物间的有效性、日常生活能力提高、神经功能恢复等结论存在争议。 |
| ABSTRACT： | OBJECTIVE： To re-evaluate t he methodology quality of published systematic review/Meta-analysis of antidepressants in the treatment of post-stroke depression. METHODS ：Retrieved from Cochrane Library ，PubMed，Embase， SinoMed，CNKI，Wanfang database ，VIP，CBM and other databases ，systematic review/Meta-analysis of antidepressants in the treatment of post-stroke depression were collected during the inception to Dec. 2019. After literature screening and data extraction ， methodology quality of included literatures were evaluated by using the AMSTAR scale. RESULTS ：A total of 33 systematic reviews/Meta-analysis were included ，involving 523 RCTs and 41 020 patients. Average score of AMSTAR methodological quality evaluation was 6.76. Citalopram ，duloxetine and paroxetine were effective for the therapy of post-stroke depression ，but the conclusions about the effectiveness among antide-pressants were not consistents. The ADR incidence of Paroxetine was low. It was not clear that sertraline and citalopram may improve the neurological function of patients. CONCLUSIONS ：The methodological quality of systematic review/Meta-analysis of antidepressants in the treatment of post-stroke depression is medium ，and the conclusions about the effectiveness of antidepressants ，improvement of daily life ability and the recovery of neurological function are still controversial. |
| 期刊： | 2020年第31卷第24期 |
| 作者： | 关月，郭桂萍，王婧雯，王明明，牟菲，乔逸，李琼阁 |
| AUTHORS： | GUAN Yue，GUO Guiping，WANG Jingwen，WANG Mingming，MOU Fei，QIAO Yi，LI Qiongge |
| 关键字： | 卒中后抑郁；AMSTAR量表；方法学；质量再评价；系统评价；Meta分析 |
| KEYWORDS： | Post-stroke depression ；AMSTAR scale ；Methodology；Quality re-evaluation ；Systematic evaluation ；Meta-analysis |
| 阅读数： | 253 次 |
| 本月下载数： | 6 次 |
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