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专利视角下我国医药中间体应用技术发展态势研究
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| 篇名： | 专利视角下我国医药中间体应用技术发展态势研究 |
| TITLE： | |
| 摘要： | 目的：协助企业了解医药中间体行业相关的技术点和发展趋势，为医药中间体应用技术提供新的发展思路和技术支持。方法：将医药中间体涉及的核心技术列为研究对象并分为四级，检索国家知识产权局专利检索系统（SIPO）及合享（INCOPAT）、智慧芽（PatSnap）专利数据库中2020年2月2日之前公开/公告的医药中间体专利数据。运用专利分析方法分析医药中间体专利申请趋势以及专利申请人，同时对医药中间体二、三级技术进行详细分析。最后运用SPSS24.0软件对我国医药中间体专利的申请数量进行曲线拟合预测分析。结果：共检索出相关专利12103条；二级技术分类下，抗生素类药物中间体专利有331条，解热镇痛药物中间体专利有474条，心血管药物中间体专利有1227条，抗癌用医药中间体专利有1550条。全球与我国医药中间体专利申请数量均逐年递增，中国大陆的专利申请数量是最多的，其中江苏、上海、山东等省份专利申请数量排名前3位；排在前10位的专利申请人中有8家为我国国内企业或高校，他们也在我国医药中间体专利申请人构成中排名前2位。医药中间体二级技术中，心血管药物中间体专利申请数量占比最大（占32％），其次是抗癌用医药中间体技术（占30％）；三级技术中，医药中间体在产品（占35％）、方法（占35％）和用途（占28％）上均有专利申请。我国医药中间体专利申请数量的曲线拟合显示，当前申请趋势与三次曲线模型拟合程度最高，并预测我国2020、2021年的专利申请数量分别为688、781件。结论：医药中间体技术在我国发展迅速，高校与企业都具备相当的研发实力；企业除了在技术创新上有所发展外，还可以考虑校企合作的发展思路以及企业间的专利交叉许可，助力我国医药中间体产业更好发展。 |
| ABSTRACT： | OBJECTIVE：To assist enterprises to understand the technical points a nd development trend of pharmaceutical intermediates industry ，and to provide new development ideas and technical support for pharmaceutical intermediates application technology. METHODS ：Taking the core technology involved in pharmaceutical intermediates as the research object and divided into four levels ，the patent data of pharmaceutical intermediates published （announced）before Feb. 2nd，2020 in State Intellectual Property Office （SIPO），INCOPAT and PatSnap patent databases were searched. Patent analysis method was used to analyze the patent application trend and patent applicants of pharmaceutical intermediates ，and the secondary and tertiary technologies of pharmaceutical intermediates were analyzed in detail. Finally ，SPSS 24.0 software was used for curve fitting prediction analysis of the number of patent applications for pharmaceutical intermediates in China. RESULTS ：A total of 12 103 related patents were retrieved. Under the secondary technology classification ，there were 331 patents for antibiotic drug intermediates ，474 patents for antipyretic and analgesic drug intermediates ，1 227 patents for cardiovascular drug intermediates ，and 1 550 patents for anticancer drug intermediates. The numbers of patent applications for pharmaceutical intermediates in the world and China were increasing year by year ，and Chinese mainland had the largest number of patent applications. The number of patent applications in Jiangsu ， Shanghai and Shandong ranked the top 3. Among the top 10 patent，8 were domestic enterprises or universities ，and they also ranked the top 2 in the composition of pharmaceutical intermediates applicants in China. Among the secondary technologies of pharmaceutical intermediates ，cardiovascular pharmaceutical intermediates accounted for the largest proportion of patent applications （32％），followed by anticancer pharmaceutical intermediates （30％）. Among the tertiary technologies ，there were patent applications for the products （35％），methods（35％）and uses （28％）of pharmaceutical intermediates. The curve fitting of the number of patent applications for pharmaceutical intermediates in China showed that the current trend of patent applications was the best fitted with the cubic curve model ，and it was predicted that the number of patent applications in 2020 and 2021 will be 688 and 781 respectively. CONCLUSIONS ：The technology of pharmaceutical intermediates has developed rapidly in China ，and universities and enterprises have considerable R&D strength. In addition to expanding in technological innovation ，enterprises can also consider the development idea of school-enterprise cooperation and patent cross licensing among enterprises to help the better deve lopment of China ’s pharmaceutical intermediates industry. |
| 期刊： | 2021年第32卷第09期 |
| 作者： | 方曦，刘跃，尤宇 |
| AUTHORS： | |
| 关键字： | 医药中间体；专利；预测；曲线估计 |
| KEYWORDS： | Pharmaceutical intermediate ；Patent；Predict；Curve estimation |
| 阅读数： | 252 次 |
| 本月下载数： | 5 次 |
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