p38MAPK信号通路在脑卒中后认知障碍中的作用及在中药防治中的药理研究进展
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篇名: | p38MAPK信号通路在脑卒中后认知障碍中的作用及在中药防治中的药理研究进展 |
TITLE: | Role of p 38 MAPK signaling pathway on post-stroke cognitive impairment and pharmacological research progress in the prevention and treatment with traditional Chinese medicine |
摘要: | 脑卒中后认知障碍(PSCI)是指由脑卒中引起的从轻度认知障碍到痴呆的一系列综合征。促分裂原活化的蛋白激酶(MAPK)信号通路是哺乳动物体内传递细胞信号一个关键路径,p38是其中的一个经典分支。p38MAPK信号通路参与了中枢神经系统疾病相关细胞生长、分化、凋亡、炎症反应等多种病理生理过程。如今,中药防治PSCI的基础实验研究取得较大进展,但缺乏相关的系统性总结。因此,本文综述了p38MAPK信号通路在PSCI中的作用及其在中药防治领域中的药理研究进展。 |
ABSTRACT: | Post-stroke cognitive impairment (PSCI) refers to a series of syndromes from mild cognitive impairment to dementia caused by stroke. The mitogen-activated protein kinases (MAPK)signaling pathway is a key pathway for transmitting cellular signals in mammals ,and p 38 is a classic branch of it. p 38 MAPK signaling pathway is involved in various pathophysiological processes such as cell growth ,differentiation,apoptosis and inflammatory response in central nervous system diseases. At present ,great progress has been made in clinical and basic experimental studies on prevention and treatment of PSCI by traditional Chinese medicine (TCM),but there is a lack of relevant systematic summary. Therefore ,this article summarizes the role of p 38 MAPK signaling pathway in PSCI and the pharmacological research progress of TCM in prevention and treatment of PSCI through p 38 MAPK signaling pathway. |
期刊: | 2022年第33卷第08期 |
作者: | 丁志敏,高静,苏凯奇,余明月,齐士魁,冯一璇,冯晓东 |
AUTHORS: | DING Zhimin ,GAO Jing,SU Kaiqi,YU Mingyue ,QI Shikui ,FENG Yixuan ,FENG Xiaodong |
关键字: | 脑卒中后认知障碍;中药;p38促分裂原活化的蛋白激酶信号通路;炎症反应 |
KEYWORDS: | post-stroke cognitive impairment ;traditional Chinese medicine ;p38 mitogen-activated protein kinase signaling |
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