淫羊藿黄酮苷类化合物生物转化的研究进展
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篇名: 淫羊藿黄酮苷类化合物生物转化的研究进展
TITLE: Research progress on the biotransformation of flavonoid glycosides in Epimedii Folium
摘要: 淫羊藿黄酮苷类化合物是淫羊藿及其同属植物的主要活性成分,根据所含糖基数目的不同分为多糖苷类化合物和低糖苷类化合物。淫羊藿多糖苷类化合物经生物转化后可生成低糖苷类化合物,后者在抗肿瘤、补肾阳、抗骨质疏松等方面的药理活性强于多糖苷类化合物。本文综述了淫羊藿黄酮苷类化合物生物转化技术的研究进展,发现通过除去糖基获得低糖苷类化合物是淫羊藿黄酮苷类化合物的主要生物转化途径;相关方法以酶水解法和微生物转化法为主,还包括植物细胞转化法、酸水解法和合成法。
ABSTRACT: Flavonoid glycosides are the main active constituents of Epimedii Folium and its related plants. They can be divided into polyglycosides and low glycosides according to the number of glycosyl group. The polyglycosides of Epimedii Folium can be transformed into low glycosides after biotransformation ;pharmacological activities of low glycosides in anti-tumor ,tonifying kidney yang and anti-osteoporosis are stronger than those of polyglycosides. In this paper , the research progress about biotransformation technology of flavonoid glycosides of Epimedii Folium was reviewed. It was found that the main biotransformation pathway of flavonoid glycosides of Epimedii Folium was to obtain low glycosides by removing glycosyl group ; related methods were mainly enzymatic hydrolysis and microbial transformation ,and also included plant cell transformation ,acid hydrolysis method and synthesis method.
期刊: 2022年第33卷第12期
作者: 张宇航,陈旺,冯自立,袁洪超,高小林,王翠萍
AUTHORS: ZHANG Yuhang ,CHEN Wang,FENG Zili,YUAN Hongchao ,GAO Xiaolin ,WANG Cuiping
关键字: 淫羊藿;黄酮苷类化合物;低糖苷类化合物;生物转化
KEYWORDS: Epimedii Folium ;flavonoid glycosides ;low glycoside ;biotransformation
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