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补肾类中成药联合PDE5抑制剂治疗勃起功能障碍有效性与安全性的网状Meta分析
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| 篇名： | 补肾类中成药联合PDE5抑制剂治疗勃起功能障碍有效性与安全性的网状Meta分析 |
| TITLE： | Efficacy and safety of kidney -tonifying Chinese patent medicine combined with PDE 5 inhibitor in the treatment of erectile dysfunction ：a network meta -analysis |
| 摘要： | 目的 系统评价补肾类中成药联合5型磷酸二酯酶（PDE5）抑制剂治疗勃起功能障碍（ED）的有效性和安全性，为临床用药提供循证参考。方法计算机检索PubMed、Embase、CochraneLibrary、WebofScience、维普网、中国生物医学文献数据库、中国知网、万方数据，收集补肾类中成药联合PDE5抑制剂（试验组）对比单用PDE5抑制剂或补肾类中成药（对照组）的随机对照试验（RCT），检索时限为建库起至2022年2月15日。筛选文献、提取资料后采用Cochrane系统评价员手册6.1.0推荐的偏倚风险评价工具对纳入文献质量进行评价；采用Stata16.0软件进行网状Meta分析；采用倒漏斗图进行发表偏倚分析。结果共纳入23项RCT，共计2417例患者，涉及苁蓉益肾颗粒、蚕茸柱天胶囊、复方玄驹胶囊、还少胶囊、山海丹颗粒、生精胶囊、十三味滋阴壮阳胶囊、疏肝益阳胶囊8种中成药。网状Meta分析结果显示，在总有效率方面，以复方玄驹胶囊联合PDE5抑制剂、生精胶囊联合PDE5抑制剂、疏肝益阳胶囊联合PDE5抑制剂的总效率较高；在国际勃起功能障碍指数评分方面，以复方玄驹胶囊联合PDE5抑制剂、苁蓉益肾颗粒联合PDE5抑制剂、蚕茸柱天胶囊联合PDE5抑制剂的评分较高；在安全性方面，以还少胶囊、山海丹颗粒、疏肝益阳胶囊的不良反应发生率较低。结论补肾类中成药联合PDE5抑制剂可改善ED患者的勃起功能，减少不良反应的发生。在疗效和安全方面，以复方玄驹胶囊联合PDE5抑制剂最佳。 |
| ABSTRACT： | OBJECTIVE To systematically review the efficacy and safety of kidney -tonifying Chinese patent medicine combined with phosphodiesterase type 5（PDE5）inhibitors in the treatment of erectile dysfunction （ED），and to provide evidence - based reference for clinical medication . METHODS Retrieved from PubMed ，Embase，Cochrane Library ，Web of Science ，VIP， China Biomedical Literature Database ，CNKI and Wanfang database ，randomized controlled trials （RCTs）of kidney -tonifying Chinese patent medicine combined with PDE 5 inhibitors（trial group ）versus PDE 5 inhibitors or kidney -tonifying Chinese patent medicine alone （control group ）were collected . The search period was from the establishment of the database to February 15，2022. After literature screening and data extraction ，the risk of bias assessment tool recommended in Cochrane System Reviewer ’s Handbook 6.1.0 was used to evaluate the quality of the included literature ；Stata 16.0 software was used for network meta -analysis； and the funnel plot was used for publication bias analysis . RESULTS A total of 23 RCTs were included ，with a total of 2 417 patients， involving 8 kinds of Chinese patent medicines ， including Congrong yishen granule ，Canrong zhutian capsule ， Compound xuanju capsule ， Huanshao capsule ， Shanhaidan granule， Shengjing capsule ， Shisanwei ziyin zhuangyang capsule，Shugan yiyang capsule . The results of network meta analysis showed that in terms of total effective rate ，Compound xuanju capsule combined with PDE 5 inhibitor，Shengjing capsule combined with PDE 5 inhibitor，Shugan yiyang capsule combined with PDE 5 inhibitor had higher total effective rate ；in terms of international index of erectile function 5，the scores of Compound xuanju capsule combined with PDE 5 inhibitor，Congrong yishen granule combined with PDE 5 inhibitor，and Canrong zhutian capsule combined with PDE 5 inhibitor were higher ；in terms of safety ，the incidence of adverse drug reactions caused by Huanshao capsule ，Shanhaidan granule and Shugan yiyang capsule were lower . CONCLUSIONS Kidney-tonifying Chinese patent medicine combined with PDE 5 inhibitor can improve the erectile function of ED patients and reduce the occurrence of adverse drug reactions . In terms of efficacy and safety ，Compound xuanju capsule combined with PDE 5 inhibitor is the best . |
| 期刊： | 2022年第33卷第18期 |
| 作者： | 王真，张丽娟，李绪杰，周梓洋，李苗秀，王从安，王永泉 |
| AUTHORS： | WANG Zhen，ZHANG Lijuan，LI Xujie，ZHOU Ziyang，LI Miaoxiu，WANG Cong ’an，WANG Yongquan |
| 关键字： | 勃起功能障碍；补肾类中成药；5型磷酸二酯酶抑制剂；Meta分析；有效性；安全性 |
| KEYWORDS： | erectile dysfunction ；kidney-tonifying Chinese patent medicine ；phosphodiesterase type 5 inhibitor；meta-analysis； |
| 阅读数： | 260 次 |
| 本月下载数： | 3 次 |
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