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环孢素A个体化用药临床预后的实验室检查指标研究进展
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| 篇名： | 环孢素A个体化用药临床预后的实验室检查指标研究进展 |
| TITLE： | Research progress on laboratory examination index of clinical prognosis in individualization of cyclosporine A |
| 摘要： | 环孢素A在器官移植以及自身免疫疾病治疗中应用广泛，由于该药存在明显的个体间代谢差异，临床使用时需要根据患者血药浓度调整给药剂量。但环孢素A的血药浓度并不能准确反映其临床预后。本文围绕外周血单个核细胞内环孢素A浓度、钙调磷酸酶活性和T细胞功能以及环孢素A代谢物浓度4个实验室检查指标，综述其与环孢素A药动学以及临床预后的相关性。结果发现以上指标对患者使用环孢素A的临床预后情况有一定的预示作用，可弥补血药浓度监测的不足，但其临床实用性还需进一步提高。 |
| ABSTRACT： | Cyclosporine A is widely used in organ transplantation and autoimmune diseases . Due to the obvious differences in metabolism between individuals ，the dosage should be adjusted according to the patient ’s blood concentration during clinical use . But the blood concentration does not reflect accurately its clinical prognosis . This article focuses on the four laboratory examination indexes following aspects ：the cyclosporine A concentration of peripheral blood mononuclear cells ，calcineurin activity ，T cell function and metabolite concentration of cyclosporine A . The relationship between them and the pharmacokinetics of cyclosporine and clinical prognosis were reviewed . It’s found that the above indicators have a certain predictive effect on the clinical prognosis of patients receiving cyclosporine A ，which can make up for the insufficiency of blood drug concentration monitoring ，and the clinical practicability needs to be further improved . |
| 期刊： | 2022年第33卷第18期 |
| 作者： | 胡锦炜，朱怀军，劳茜莹，李丹滢 |
| AUTHORS： | HU Jinwei ，ZHU Huaijun ，LAO Qianying ，LI Danying |
| 关键字： | 环孢素A；治疗药物监测；临床疗效；安全性；实验室检查指标 |
| KEYWORDS： | cyclosporine A ；therapeutic drug monitoring ；clinical effi cacy；safety；laboratory examination index |
| 阅读数： | 402 次 |
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