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基于循证证据的睡眠障碍超说明书用药处方前置审核
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| 篇名： | 基于循证证据的睡眠障碍超说明书用药处方前置审核 |
| TITLE： | Evidence-based pre -prescribing review to standardize off -label drug use for sleep disorders |
| 摘要： | 目的 为规范医院睡眠障碍处方中的超说明书用药情况提供参考。方法统计并分析我院睡眠障碍处方中的超说明书用药情况，运用循证医学证据对其进行评价，对达到我院超说明书用药备案标准的予以备案，并在处方前置审核系统上修改药品审核规则；对不合理的超说明书用药处方，在处方前置审核系统中设置拦截规则。结果我院睡眠障碍处方中有超说明书用药的占总处方的36.92%，主要包括超适应证用药、超给药频次用药、超剂量用药。药师修改药品审核规则后，合理的超说明书用药处方被系统自动审核通过，不合理的超说明书用药处方被系统拦截。结论我院睡眠障碍处方中超说明书用药存在一定的合理性，药师可通过不断完善超说明书用药规范化管理，修订处方前置审核系统药品审核规则来进一步规范睡眠障碍超说明书用药，以保证睡眠障碍相关治疗药物使用的安全、合理、有效。 |
| ABSTRACT： | OBJECTIVE To provide reference for standardizing off -label drug use for sleep disorders in hospitals . METHODS The off -label drug use for sleep disorders in our hospital was analyzed statistically ，and then was evaluated with evidence -based medical evidence . The records that met the filing standards for off -label drug use should be filed ，and the drug review rules should be modified in the pre -prescribing review system . The blocking rules in the pre -prescribing review system were set up for unreasonable off -label drug use . RESULTS Off-label drug use for sleep disorders in our hospital accounted for 36.92% of total number of prescriptions ，including drug use of off -indication，over-frequency，over-dose. After the pharmacists modified the drug review rules ，the rational off -label drug use system would be automatically reviewed and approved ，and the unreasonable off -label drug use system would be intercepted . CONCLUSIONS There is a certain rationality in off -label drug use for sleep disorders . The pharmacists can further standardize off -label drug use for sleep disorders by continuously improving the standardized management of off-label drug use and revising the drug review rules of pre -prescribing review system ，so as to ensure the safe ，reasonable and effective use of drugs related to sleep disorders . |
| 期刊： | 2022年第33卷第19期 |
| 作者： | 马靖，李晨 |
| AUTHORS： | |
| 关键字： | 超说明书用药；睡眠障碍；处方前置审核；循证医学；审核规则 |
| KEYWORDS： | off-label drug use ；sleep disorder ；pre-prescribing review ；evidence-based medicine ；review rules |
| 阅读数： | 209 次 |
| 本月下载数： | 11 次 |
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