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化橘红提取物对幼龄大鼠厌食症的改善作用研究
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| 篇名： | 化橘红提取物对幼龄大鼠厌食症的改善作用研究 |
| TITLE： | Study on improvement effects of Citri Grandis Exocarpium extract on anorexia in immature rats |
| 摘要： | 目的 探究化橘红提取物对厌食症模型幼龄大鼠的药效学作用。方法随机选取10只幼龄大鼠作为对照组给予常规饲料，其余50只幼龄大鼠采用病因模拟法建立厌食症模型，将造模成功的幼龄大鼠分成模型组、健胃消食片组（0.65g/kg）和化橘红提取物低剂量（0.5g/kg）、中剂量（1.0g/kg）、高剂量（2.0g/kg）组。连续灌胃给药14d后，观察各组大鼠体质量及摄食量变化，检测胃酸浓度、胃蛋白酶活性，以及血清中胃泌素（GAS）、胃动素（MTL）、抑胃肽（GIP）水平，观察胃组织病理变化情况。结果与对照组比较，模型组幼龄大鼠摄食量、胃酸浓度、胃蛋白酶活性、GAS、MTL水平显著下降，GIP水平显著升高（P＜0.05）；胃组织病理学检查出现明显胃黏膜充血、上皮细胞松解脱落现象。与模型组比较，各给药组经药物干预后，上述指标均有不同程度的改善，胃组织病理损伤减轻。结论化橘红提取物通过调节胃酸浓度、胃蛋白酶活性、GAS、MTL、GIP水平，改善胃动力，保护胃黏膜，从而改善幼龄大鼠的厌食症。 |
| ABSTRACT： | OBJECTIVE To investigate the pharmacodynamic effects of the Citri Grandis Exocarpium extract on anorexia model immature rats.METHODS Ten immature rats were randomly selected as the control group and given regular diet， while anorexia model was induced in the remaining 50 immature rats using the etiological simulation method. The immature model rats were divided into the model group， Jianwei xiaoshi tablet group （0.65 g/kg）， Citri Grandis Exocarpium extract low-dose， medium- dose and high-dose groups （0.5， 1.0， 2.0 g/kg）. After 14 d of continuous intragastric administration， the body mass and food intake of rats in each group were observed， and the gastric acid concentration， pepsinase activity， serum levels of gastrin （GAS）， motilin （MTL） and gastric inhibitory peptide （GIP） were measured. The histopathological changes in the gastric tissue were observed.RESULTS Compared with control group， the food intake， gastric acid concentration， pepsin activity， the levels of GAS and MTL were significantly decreased and GIP level was significantly increased in the immature rats of model group （P＜0.05）； gastric histopathological examination showed significant gastric mucosal congestion and loosening and detachment of epithelial cells. Compared with model group， all administration groups showed different degrees of improvement in the above indexes and decreased gastric histopathological damage after drug intervention.CONCLUSIONS Citri Grandis Exocarpium extract improves gastric motility and protects gastric mucosa in the immature rats by regulating the concentration of gastric acid， pepsin activity， the levels of GAS， MTL and GIP， thus improving anorexia in immature rats. |
| 期刊： | 2022年第33卷第23期 |
| 作者： | 刘佳，吴道顺，潘云风，王艳慧，罗云，孙晓波 |
| AUTHORS： | LIU Jia，WU Daoshun，PAN Yunfeng，WANG Yanhui，LUO Yun，SUN Xiaobo |
| 关键字： | 化橘红提取物；厌食症；胃蛋白酶；胃泌素；胃动素；抑胃肽 |
| KEYWORDS： | Citri Grandis Exocarpium extract； anorexia； pepase； gastrin； motilin； gastric inhibitory peptide |
| 阅读数： | 244 次 |
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