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多糖类成分抗胰腺癌作用机制的研究进展
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| 篇名： | 多糖类成分抗胰腺癌作用机制的研究进展 |
| TITLE： | Research progress on the effect mechanism of polysaccharides against pancreatic cancer |
| 摘要： | 多糖是公认的免疫调节剂，已被证实对多种癌细胞具有抑制作用，具有开发为抗癌药物的潜力。胰腺癌作为病死率最高的癌症之一，长期采用化疗药物治疗，易产生免疫缺陷、疲劳、神经系统病变等多种副作用。本文总结了国内外多糖类成分抗胰腺癌的研究现状，梳理出多糖类成分可以通过多靶点的作用方式，调控核因子κB、Hippo-转录共激活因子相关蛋白、整合素等相关信号通路，诱导癌细胞凋亡、自噬，抑制癌细胞增殖、迁移与侵袭，调控癌细胞周期，从而发挥抗胰腺癌的作用。 |
| ABSTRACT： | Polysaccharide is a recognized immunomodulator that has been shown to have inhibitory effects on a variety of cancer cells and has the potential to be developed as an anti-cancer drug. Pancreatic cancer， one of the cancers with the highest mortality rate， is treated with long-term chemotherapeutic drugs and is prone to a variety of side effects such as immune deficiency， fatigue， and neurological lesions. The polysaccharide anti-pancreatic cancer research landscape both domestically and internationally is summarized in this publication. By regulating nuclear factor-κB， Hippo-Yes-associated protein， integrin and other signaling pathways， polysaccharide components play an anti-pancreatic cancer role by multi-target ways， such as inducing apoptosis and autophagy， inhibiting proliferation， migration and invasion of cancer cells， and regulating the cancer cell cycle. |
| 期刊： | 2023年第34卷第01期 |
| 作者： | 刘光宇；王琦；苏玲 |
| AUTHORS： | LIU Guangyu，WANG Qi，SU Ling |
| 关键字： | 多糖；胰腺癌；作用机制 |
| KEYWORDS： | polysaccharide； pancreatic cancer； effect mechanism |
| 阅读数： | 225 次 |
| 本月下载数： | 8 次 |
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