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熵权法-层次分析法结合Box-Behnken响应面法优化雪莲益肾方的提取工艺
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| 篇名： | 熵权法-层次分析法结合Box-Behnken响应面法优化雪莲益肾方的提取工艺 |
| TITLE： | Optimization of the extraction process for Xuelian yishen formula by the combination of entropy weight method-analytic hierarchy process with Box-Behnken response surface methodology |
| 摘要： | 目的 优选雪莲益肾方的提取工艺。方法以雪莲益肾方中总黄酮、松果菊苷、毛蕊花糖苷含量及出膏率为考察指标，采用熵权法-层次分析法确定各指标的综合权重系数；以提取时间、料液比和提取次数为考察因素，上述各指标的综合评分为评价指标，基于Box-Behnken响应面法设计实验，优化雪莲益肾方的提取工艺。结果雪莲益肾方的最优提取工艺为提取时间2h、料液比1∶12、提取次数3次。3次验证实验的平均综合评分为96.40分（RSD为0.28%），与模型预测值的偏差为0.98%。结论本研究优化后的工艺稳定可行、重复性好，可为雪莲益肾方的提取工艺提供参考。 |
| ABSTRACT： | OBJECTIVE To optimize the extraction process of Xuelian yishen formula. METHODS The contents of total flavone， echinacoside and acteoside， and extraction yield in Xuelian yishen formula were chosen as indexes， entropy weight method-analytic hierarchy process was adopted to determine the weight coefficient. Box-Behnken response surface methodology was used to optimize the extraction process of Xuelian yishen formula with extraction time， solid-liquid ratio and extraction times as factors， using comprehensive score of above indexes as index. RESULTS The optimal extraction process of Xuelian yishen formula was extraction time of 2 h， solid-liquid ratio of 1∶12， extracting for 3 times. Average comprehensive score of 3 validation tests was 96.40 points （RSD＝0.28%）， the deviation of which with predictive value was 0.98%. CONCLUSIONS The optimized extraction process is stable， feasible and reproducible， which can provide reference for the extraction process of Xuelian yishen formula. |
| 期刊： | 2023年第34卷第15期 |
| 作者： | 夏提古丽·塔西买买提；赵媛；刘艺；邓德强；阿吉艾克拜尔·艾萨；吴涛 |
| AUTHORS： | Xiatiguli·Taximaimaiti，ZHAO Yuan，LIU Yi，DENG Deqiang，Haji-akber·Aisa，WU Tao |
| 关键字： | 雪莲益肾方；熵权法；层次分析法；Box-Behnken响应面法；提取工艺 |
| KEYWORDS： | Xuelian yishen formula； entropy weight method； analytic hierarchy process method； Box-Behnken response |
| 阅读数： | 61 次 |
| 本月下载数： | 2 次 |
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